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SGLT2i as 1L therapy for CKD: How to optimize real-world prescription?

29 Aug 2024 by

Kidney Disease: Improving Global Outcomes (KDIGO) 2024 clinical practice guideline recommends sodium-glucose cotransporter 2 inhibitors (SGLT2i) as first-line (1L) therapy for most patients with chronic kidney disease (CKD), with or without diabetes. Despite the established cardiorenal benefits of SGLT2i, prescription remains suboptimal in real-world CKD populations. At Advances in Medicine (AIM) 2024, Professor Jennifer Green of Duke University Medical Center in Durham, North Carolina, US, discussed empagliflozin’s cardiorenal benefits in broad CKD populations and the importance of early initiation of SGLT2i therapy in delaying CKD progression, while Dr Jack Ng of the Chinese University of Hong Kong presented strategies for optimizing SGLT2i prescription in CKD.

SGLT2i as 1L therapy for CKD: How to optimize real-world prescription?

29 Aug 2024

Novel GLP-1/GCG receptor agonist shows promise against noncirrhotic MASH with fibrosis

29 Aug 2024

Dual glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptor agonism with cotadutide has shown a signal of benefit in the treatment of noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis, according to the phase II PROXYMO trial.

Novel GLP-1/GCG receptor agonist shows promise against noncirrhotic MASH with fibrosis

29 Aug 2024

Add-on niraparib maintenance confers PFS benefit in endometrial cancer

29 Aug 2024 by

The addition of a PARP inhibitor (PARPi), niraparib, to dostarlimab plus chemotherapy significantly improved progression-free survival (PFS) among patients with primary advanced or recurrent endometrial cancer, including those with mismatch repair proficient (MMRp)/microsatellite stable (MSS) tumours, according to results from part 2 of the RUBY trial presented at ESMO Gyn 2024.

Add-on niraparib maintenance confers PFS benefit in endometrial cancer

29 Aug 2024

Use of an amyloid β–directed antibody in Alzheimer’s disease

29 Aug 2024 by

A 72-year-old male retired university lecturer with no family history of memory issues recently exhibited signs of memory decline, as observed by his family. The patient did not perceive any significant memory issues in himself and did not view himself as forgetful. He acknowledged that he may not remember things if he lacked interest in them or could not connect them to something familiar.

Use of an amyloid β–directed antibody in Alzheimer’s disease

29 Aug 2024

Dad’s preconception HBV infection tied to baby’s heart defects

28 Aug 2024 by

A preconception history of hepatitis B virus (HBV) infection among fathers carries an increased risk of congenital heart disease (CHD) in offspring, as shown in a study.

Dad’s preconception HBV infection tied to baby’s heart defects

28 Aug 2024

AI-based ECG predicts biventricular dysfunction, dilation in CHD

28 Aug 2024

An ECG enhanced by artificial intelligence (AI) demonstrates its capability in detecting biventricular dysfunction and dilation in patients with congenital heart disease (CHD).

AI-based ECG predicts biventricular dysfunction, dilation in CHD

28 Aug 2024

Rivaroxaban eases ischaemic events, ups bleeding in frail patients after revascularization

28 Aug 2024 by

The risks of ischaemic complications and bleeding are higher among patients with peripheral artery disease (PAD) who meet the frailty criteria after lower extremity revascularization in the VOYAGER PAD study. Regardless of frailty status, use of rivaroxaban lowers the ischaemic risk and increases bleeding.

Rivaroxaban eases ischaemic events, ups bleeding in frail patients after revascularization

28 Aug 2024

Skipping breakfast, night eating tied to faster weight gain

28 Aug 2024

People who frequently skip breakfast and eat at night have faster increases in weight and waist circumference (WC), according to a China study.

Skipping breakfast, night eating tied to faster weight gain

28 Aug 2024

Metformin, SGLT2is confer protection against dementia

28 Aug 2024

Among various glucose-lowering medications, metformin and sodium glucose co-transporter-2 inhibitors (SGLT2is) are associated with a reduced risk of dementia, as shown in the results of a meta-analysis.

Metformin, SGLT2is confer protection against dementia

28 Aug 2024

Gestational diabetes linked to altered gut microbiome and larger head circumference in male offspring

28 Aug 2024 by

Gestational diabetes mellitus (GDM) not only disrupts the gut microbiome of mothers and their infants, but is also linked to increased head circumference in male offspring, researchers from the Chinese University of Hong Kong (CUHK) have shown.

Gestational diabetes linked to altered gut microbiome and larger head circumference in male offspring

28 Aug 2024

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SGLT2i as 1L therapy for CKD: How to optimize real-world prescription?

SGLT2i as 1L therapy for CKD: How to optimize real-world prescription?

Novel GLP-1/GCG receptor agonist shows promise against noncirrhotic MASH with fibrosis

Novel GLP-1/GCG receptor agonist shows promise against noncirrhotic MASH with fibrosis

Add-on niraparib maintenance confers PFS benefit in endometrial cancer

Add-on niraparib maintenance confers PFS benefit in endometrial cancer

Use of an amyloid β–directed antibody in Alzheimer’s disease

Use of an amyloid β–directed antibody in Alzheimer’s disease

Dad’s preconception HBV infection tied to baby’s heart defects

Dad’s preconception HBV infection tied to baby’s heart defects

AI-based ECG predicts biventricular dysfunction, dilation in CHD

AI-based ECG predicts biventricular dysfunction, dilation in CHD

Rivaroxaban eases ischaemic events, ups bleeding in frail patients after revascularization

Rivaroxaban eases ischaemic events, ups bleeding in frail patients after revascularization

Skipping breakfast, night eating tied to faster weight gain

Skipping breakfast, night eating tied to faster weight gain

Metformin, SGLT2is confer protection against dementia

Metformin, SGLT2is confer protection against dementia

Gestational diabetes linked to altered gut microbiome and larger head circumference in male offspring

Gestational diabetes linked to altered gut microbiome and larger head circumference in male offspring