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HCC in SG: NASH aetiology on the rise, curative therapy more accessible

05 Oct 2021 by

Hepatocellular carcinoma (HCC) in Singapore has changed markedly throughout the last decade, with patients being diagnosed at an increasingly older age and cryptogenic cirrhosis/nonalcoholic steatohepatitis (NASH) becoming a more important aetiology, according to a recent study.

HCC in SG: NASH aetiology on the rise, curative therapy more accessible

05 Oct 2021

Leuprolide acetate maintains QOL scores in prostate cancer patients despite worsening condition

05 Oct 2021

Treatment with leuprolide acetate every 6 months does not elicit significant changes in health-related quality of life (HRQOL) among prostate cancer (PC) patients despite substantial deterioration of body and role functions, a recent study has found.

Leuprolide acetate maintains QOL scores in prostate cancer patients despite worsening condition

05 Oct 2021

COVID-19 in childhood cancer patients: What are the risk factors?

04 Oct 2021 by

A large international database study has shown that children and adolescents with cancer have an elevated risk of severe or critical disease if infected with COVID-19. Furthermore, about half the patients receiving cancer therapy experienced modifications to their treatment regimens.

COVID-19 in childhood cancer patients: What are the risk factors?

04 Oct 2021

Original New Drug Application Approvals by US FDA (16-30 September 2021)

04 Oct 2021

New drug applications approved by US FDA as of 16 -30 September 2021 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16-30 September 2021)

04 Oct 2021

Dose escalation intolerance disrupts maintenance therapy of children with ALL

03 Oct 2021

Only a few children with acute lymphoblastic leukaemia (ALL) treated with mercaptopurine (6MP) and methotrexate (MTX) complete their maintenance therapy without interruptions at the current dose escalation schedules outlined by the Children’s Oncology Group protocols, a study has shown.

Dose escalation intolerance disrupts maintenance therapy of children with ALL

03 Oct 2021

Drug interactions in breast cancer therapy may harm patients

02 Oct 2021

Several drug-drug interactions (DDIs) found in breast cancer treatment may lead to adverse consequences on patient health and therapeutic outcomes, suggests a study.

Drug interactions in breast cancer therapy may harm patients

02 Oct 2021

TKIs safe, effective as first-line therapy in cytokine-intolerant metastatic renal cell cancer

02 Oct 2021

Tyrosine kinase inhibitors (TKIs) are a safe and effective first-line treatment for metastatic renal cell cancer (mRCC), confirms a Turkey study. In addition, no significant difference has been observed among three TKI agents (sunitinib, pazopanib, and sorafenib) in terms of treatment duration, overall response rate (ORR), progression-free survival (PFS), and overall survival (OS).

TKIs safe, effective as first-line therapy in cytokine-intolerant metastatic renal cell cancer

02 Oct 2021

HPV status affects survival in penile intraepithelial neoplasia patients

02 Oct 2021

In patients with penile intraepithelial neoplasia (PeIN), testing positive for p16 overexpression, as a surrogate marker for high-risk human papillomavirus (HPV), correlates with longer disease-free survival (DFS), a recent study has found. Moreover, combination treatment with immunotherapy seems to boost response regardless of p16 status.

HPV status affects survival in penile intraepithelial neoplasia patients

02 Oct 2021

Muscle wasting shortens postsurgery survival in older CRC patients

30 Sep 2021

Muscle wasting is a risk factor for death in older patients undergoing colorectal cancer (CRC) surgery, a recent study has found.

Muscle wasting shortens postsurgery survival in older CRC patients

30 Sep 2021

Neoadjuvant vismodegib reduces need for surgery in periocular basal cell carcinoma

30 Sep 2021

Neoadjuvant treatment with vismodegib achieves mixed clinical and histological response in periocular basal cell carcinoma (BCC) but limits the need for extensive surgery, a recent study has found. Final surgical excision improves outcomes, leading to clear margins and low recurrence rates.

Neoadjuvant vismodegib reduces need for surgery in periocular basal cell carcinoma

30 Sep 2021

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HCC in SG: NASH aetiology on the rise, curative therapy more accessible

HCC in SG: NASH aetiology on the rise, curative therapy more accessible

Leuprolide acetate maintains QOL scores in prostate cancer patients despite worsening condition

Leuprolide acetate maintains QOL scores in prostate cancer patients despite worsening condition

COVID-19 in childhood cancer patients: What are the risk factors?

COVID-19 in childhood cancer patients: What are the risk factors?

Original New Drug Application Approvals by US FDA (16-30 September 2021)

Original New Drug Application Approvals by US FDA (16-30 September 2021)

Dose escalation intolerance disrupts maintenance therapy of children with ALL

Dose escalation intolerance disrupts maintenance therapy of children with ALL

Drug interactions in breast cancer therapy may harm patients

Drug interactions in breast cancer therapy may harm patients

TKIs safe, effective as first-line therapy in cytokine-intolerant metastatic renal cell cancer

TKIs safe, effective as first-line therapy in cytokine-intolerant metastatic renal cell cancer

HPV status affects survival in penile intraepithelial neoplasia patients

HPV status affects survival in penile intraepithelial neoplasia patients

Muscle wasting shortens postsurgery survival in older CRC patients

Muscle wasting shortens postsurgery survival in older CRC patients

Neoadjuvant vismodegib reduces need for surgery in periocular basal cell carcinoma

Neoadjuvant vismodegib reduces need for surgery in periocular basal cell carcinoma