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Ribociclib plus endocrine therapy: A win for early breast cancer?

16 Jun 2023 by

In the second interim efficacy analysis of the phase III NATALEE trial, a combination regimen comprising the CDK4/6 inhibitor ribociclib and endocrine therapy (ET) demonstrated favourable signals for the adjuvant treatment of stage II/III hormone receptor-positive, HER2-negative (HR+, HER2–) early breast cancer.

Ribociclib plus endocrine therapy: A win for early breast cancer?

16 Jun 2023

Original New Drug Application Approvals by US FDA (01-15 June 2023)

16 Jun 2023

New drug applications approved by US FDA as of 01-15 June 2023 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (01-15 June 2023)

16 Jun 2023

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

16 Jun 2023

Antifibrotic treatment appears to put brakes on the decline of lung function, as evidenced by forced vital capacity (FVC) measurements, in patients with interstitial lung disease (ILD) related to connective tissue disease (CTD) or rheumatoid arthritis (RA), according to a study.

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

16 Jun 2023

Telitacicept tied to higher SRI-4 response in SLE patients

16 Jun 2023 by

Among patients with active systemic lupus erythematosus (SLE), treatment with telitacicept significantly increased SLE Responder Index 4 (SRI-4) response rate at week 52 compared with placebo, according to a study presented at EULAR 2023.

Telitacicept tied to higher SRI-4 response in SLE patients

16 Jun 2023

Teduglutide effective in children with SBS, but still costly

15 Jun 2023 by

Use of teduglutide is effective against short bowel syndrome (SBS) in paediatric patients, although some children need a longer duration of treatment to achieve enteral autonomy, according to a Spain study presented at ESPGHAN 2023. Predictive factors of response to treatment have not been identified.

Teduglutide effective in children with SBS, but still costly

15 Jun 2023

Pain mechanisms tied to disease activity in DMARD-treated RA

15 Jun 2023

A recent study has shown the importance of identifying and treating aberrant peripheral and central pain regulation in patients with rheumatoid arthritis (RA) who are either initiating or switching to disease-modifying antirheumatic drug (DMARD) treatment.

Pain mechanisms tied to disease activity in DMARD-treated RA

15 Jun 2023

Dupilumab shows benefit in young children with EoE

15 Jun 2023 by

Treatment with dupilumab significantly improves histologic and endoscopic measures of eosinophilic esophagitis (EoE) in young children aged 1–11 years, according to the phase III EoE KIDS trial presented at ESPGHAN 2023.

Dupilumab shows benefit in young children with EoE

15 Jun 2023

Sacubitril/valsartan outdoes valsartan on ventricular remodeling in perimenopausal hypertension

14 Jun 2023

Treatment with sacubitril/valsartan appears to be better than valsartan alone in reversing ventricular remodeling in perimenopausal hypertensive women, suggests a study.

Sacubitril/valsartan outdoes valsartan on ventricular remodeling in perimenopausal hypertension

14 Jun 2023

Methotrexate poses no risk for men seeking parenthood

13 Jun 2023 by

Treatment with methotrexate (MTX) does not appear to be associated with testicular toxicity, according to the results of the iFAME-MTX study, dispelling concerns about the effect of the drugs among men wishing to become a parent and their clinicians.

Methotrexate poses no risk for men seeking parenthood

13 Jun 2023

Loperamide, mitragynine linked to ventricular arrhythmias

13 Jun 2023

Use of nonprescription drugs loperamide and mitragynine appears to contribute to the risk of life-threatening ventricular arrhythmia, reports a study in North America.

Loperamide, mitragynine linked to ventricular arrhythmias

13 Jun 2023

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Ribociclib plus endocrine therapy: A win for early breast cancer?

Ribociclib plus endocrine therapy: A win for early breast cancer?

Original New Drug Application Approvals by US FDA (01-15 June 2023)

Original New Drug Application Approvals by US FDA (01-15 June 2023)

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

Telitacicept tied to higher SRI-4 response in SLE patients

Telitacicept tied to higher SRI-4 response in SLE patients

Teduglutide effective in children with SBS, but still costly

Teduglutide effective in children with SBS, but still costly

Pain mechanisms tied to disease activity in DMARD-treated RA

Pain mechanisms tied to disease activity in DMARD-treated RA

Dupilumab shows benefit in young children with EoE

Dupilumab shows benefit in young children with EoE

Sacubitril/valsartan outdoes valsartan on ventricular remodeling in perimenopausal hypertension

Sacubitril/valsartan outdoes valsartan on ventricular remodeling in perimenopausal hypertension

Methotrexate poses no risk for men seeking parenthood

Methotrexate poses no risk for men seeking parenthood

Loperamide, mitragynine linked to ventricular arrhythmias

Loperamide, mitragynine linked to ventricular arrhythmias