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Does paternal use of metformin up risk for congenital malformations?

21 Jun 2024

Use of metformin monotherapy by fathers during the sperm development period prior to conception does not appear to contribute to an increased risk of major congenital malformations (MCMs) in newborns, reveals a study.

Does paternal use of metformin up risk for congenital malformations?

21 Jun 2024

Original New Drug Application Approvals by US FDA (1-15 June 2024)

21 Jun 2024

New drug applications approved by US FDA as of 1-15 June 2024 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (1-15 June 2024)

21 Jun 2024

Weekly tirzepatide works for weight loss in Chinese adults with obesity

20 Jun 2024

Once-weekly treatment with tirzepatide at either 10 or 15 mg appears to yield substantial reductions in weight, according to data from the phase III SURMOUNT-CN trial.

Weekly tirzepatide works for weight loss in Chinese adults with obesity

20 Jun 2024

Simplified questionnaire aims to improve early PN diagnosis

18 Jun 2024 by

Early recognition of peripheral neuropathy (PN) is crucial to prevent or delay disease progression and development of associated complications. In an interview with MIMS Doctor, Dr Vivien Lim, Specialist in Endocrinology at the Gleneagles Medical Centre in Singapore, discussed potential reasons for delayed PN diagnosis, particularly in patients with diabetes mellitus (DM). She also introduced a simple questionnaire developed by a panel of neurologists and endocrinologists for both patients and physicians, to urge early detection of PN in the primary care setting.

Simplified questionnaire aims to improve early PN diagnosis

18 Jun 2024

Duodenal switch not necessarily better than RYGB for patients with high BMI

17 Jun 2024

In the treatment of patients with a BMI of 50–60 kg/m2, duodenal switch (DS) appears to result in better weight loss outcomes but also more frequent adverse events, including nutritional complications, as compared with Roux-en-Y-gastric bypass (RYGB), according to an open-label study.

Duodenal switch not necessarily better than RYGB for patients with high BMI

17 Jun 2024

Role of fibre in management of metabolic diseases

12 Jun 2024 by

Lifestyle interventions, including increased fibre intake, have been shown to be effective in management of metabolic diseases. At a meeting coordinated by the Hong Kong College of Family Physicians (HKCFP), Dr Elaine Chow of the Department of Medicine & Therapeutics, the Chinese University of Hong Kong, described different types of dietary fibre and their various benefits, and shared clinical evidence on the role of psyllium fibre in minimizing cardiometabolic risk factors, such as elevated LDL-cholesterol (LDL-C), blood glucose levels and obesity.

Role of fibre in management of metabolic diseases

12 Jun 2024

Olezarsen benefits hypertriglyceridemia patients at high cardiovascular risk

10 Jun 2024

Treatment with olezarsen in patients with hypertriglyceridemia and elevated cardiovascular risk results in substantial reductions in triglyceride, apolipoprotein B, and non–high-density lipoprotein cholesterol levels, while having no major safety signals, according to data from the phase IIb Bridge–TIMI 73a study.

Olezarsen benefits hypertriglyceridemia patients at high cardiovascular risk

10 Jun 2024

Gastric fundus ablation targets hunger hormone for weight loss

08 Jun 2024 by

Ablating the gastric fundus to reduce the production of the hunger hormone ghrelin helps women curb their appetite and lose body weight in the ABLATE-WEIGHT first-in-human trial.

Gastric fundus ablation targets hunger hormone for weight loss

08 Jun 2024

Newer glucose-lowering drugs best sulfonylureas, glinides in second-line treatment of T2D

07 Jun 2024

Glucose-lowering drugs such as the glucagon-like peptide-1 receptor agonist (GLP-1-RA), sodium-glucose cotransporter 2 inhibitor (SGLT2i), and dipeptidyl peptidase-4 inhibitor (DPP-4i) work better and are more cost-effective than sulfonylureas and glinides (SU) as second-line treatment for type 2 diabetes (T2D), according to a population-based retrospective cohort study.

Newer glucose-lowering drugs best sulfonylureas, glinides in second-line treatment of T2D

07 Jun 2024

Low-carb diet eases pain, improves QoL in women with lipedema

06 Jun 2024

Women with lipedema who lose weight through proper diet can see improvements in their quality of life (QoL), suggests a study. Specifically, an energy-restricted low-carbohydrate diet (LCD) appears to be better at pain reduction than a standard control diet.

Low-carb diet eases pain, improves QoL in women with lipedema

06 Jun 2024

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Does paternal use of metformin up risk for congenital malformations?

Does paternal use of metformin up risk for congenital malformations?

Original New Drug Application Approvals by US FDA (1-15 June 2024)

Original New Drug Application Approvals by US FDA (1-15 June 2024)

Weekly tirzepatide works for weight loss in Chinese adults with obesity

Weekly tirzepatide works for weight loss in Chinese adults with obesity

Simplified questionnaire aims to improve early PN diagnosis

Simplified questionnaire aims to improve early PN diagnosis

Duodenal switch not necessarily better than RYGB for patients with high BMI

Duodenal switch not necessarily better than RYGB for patients with high BMI

Role of fibre in management of metabolic diseases

Role of fibre in management of metabolic diseases

Olezarsen benefits hypertriglyceridemia patients at high cardiovascular risk

Olezarsen benefits hypertriglyceridemia patients at high cardiovascular risk

Gastric fundus ablation targets hunger hormone for weight loss

Gastric fundus ablation targets hunger hormone for weight loss

Newer glucose-lowering drugs best sulfonylureas, glinides in second-line treatment of T2D

Newer glucose-lowering drugs best sulfonylureas, glinides in second-line treatment of T2D

Low-carb diet eases pain, improves QoL in women with lipedema

Low-carb diet eases pain, improves QoL in women with lipedema