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PARG inhibition slows HCC progression, boosts efficacy of immune checkpoint therapy

PARG inhibition slows HCC progression, boosts efficacy of immune checkpoint therapy

05 Jul 2022

In hepatocellular carcinoma (HCC), poly(ADP-ribose) glycohydrolase (PARG) may serve as an oncogene by modulating PARG/DDB1/c-Myc signaling and be used as a biomarker to identify HCC patients who may derive benefit from anti-PD-1 treatment, suggests a study.

PARG inhibition slows HCC progression, boosts efficacy of immune checkpoint therapy

05 Jul 2022
NAFLD linked to heightened type 2 diabetes risk

NAFLD linked to heightened type 2 diabetes risk

22 Jun 2022

Children with nonalcoholic fatty liver disease (NAFLD) are at an increased risk of type 2 diabetes, a study reports. Other risk factors for T2D include severity of liver histology, body mass index, and female sex.

NAFLD linked to heightened type 2 diabetes risk

22 Jun 2022