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Mevrometostat plus enzalutamide improves outcomes in mCRPC patients
Treatment with mevrometostat (MEV), an enhancer of zeste homolog 2 inhibitor, in combination with enzalutamide (ENZ) results in better survival outcomes and response than ENZ alone among patients with metastatic castration-resistant prostate cancer (mCRPC), reports a study presented at ASCO GU 2025. The combined therapy also demonstrates a favourable safety profile.
Prenatal COVID-19 infection, vaccination: Early child developmental concerns allayed
Neither SARS-CoV-2 infection exposure nor COVID-19 vaccination during pregnancy poses a significant risk to early child development, as shown in a population-level study said to be the largest to date.
First-line nivolumab-ipilimumab therapy extends survival in unresected HCC
Treatment with nivolumab plus ipilimumab in the frontline setting provides clinically meaningful overall survival (OS) benefit compared with lenvatinib or sorafenib to patients with unresectable hepatocellular carcinoma (HCC) who were naive to systemic therapy, according to data from the phase III CheckMate 9DW study presented at ASCO GI 2025.
Is it safe to administer RSV vax with flu or COVID-19 vaccines in adults?
A two-part phase III study in adults aged ≥50 years supports the co-administration of the respiratory syncytial virus (RSV) vaccine, mRNA-1345, with the seasonal standard-dose quadrivalent inactivated influenza vaccine, SIIV4, or the bivalent COVID-19 vaccine, mRNA-1273.214.
