News & Updates

In the treatment of patients with atrial fibrillation (AF) and moderate-to-high risk of stroke, abelacimab appears more beneficial than rivaroxaban, having been associated with lower free factor XI levels and fewer bleeding events in the phase IIB AZALEA–TIMI 71 study.

Nanostructured lipid carriers (NLCs) delivering pitavastatin demonstrated potential for glioblastoma (GB) treatment in a systematic benchtop study.

Patients with hepatocellular carcinoma (HCC) who are receiving treatment with the combination of atezolizumab plus bevacizumab may be at risk of variceal bleeding, particularly those with a low platelet count, portal vein invasion, history of gastrointestinal bleeding, and varices needing treatment, as shown in a retrospective study.

Faecal microbiota transplantation (FMT) with standardized anaerobic cultivated human intestinal microbiome is safe but does not appear to be efficacious in patients with systemic sclerosis experiencing lower gastrointestinal (GI) tract symptoms, according to a phase II study.

Dual immunotherapy with checkpoint inhibitors nivolumab and ipilimumab works better to slow disease progression in patients with microsatellite instability-high or mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC) when compared with single-agent nivolumab, as shown in the phase III CheckMate 8HW trial.

Pregnant women who use glucocorticoids may put their offspring at risk of certain mental disorders, according to a large cohort study.

Preliminary data from an observational case–control study have shown that selexipag is safe and effective in the treatment of systemic sclerosis vasculopathy, particularly digital ulcers (DUs) and Raynaud phenomenon (RP).

Hospitalized preterm infants who received routine 2-month vaccinations were more likely to experience an apnoea episode within 48 hours than those who did not receive any vaccinations, according to a recent study.

For pregnant women with type 1 diabetes (T1D), continued use of hybrid-closed loop (HCL) insulin through the postpartum period appears to be safe and efficacious, helping maintain blood sugar control for a significant portion of the time without an increase in hypoglycaemia.

The use of gabapentin is effective in reducing neuropathic pain due to paclitaxel chemotherapy, as shown in a study.