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Rheumatic patients report lower anxiety, self-isolation levels after initial lockdown
Patients with inflammatory rheumatic disease (IRD) have reduced levels of anxiety and self-isolation following the initial lockdown period brought about by the COVID-19 pandemic, reports a study.

Post-exposure doxycycline prevents STIs in MSM, TGW with HIV or on PrEP
Doxycycline, taken with 72 hours of unprotected sex, could prevent sexually transmitted infections (STIs) in men who have sex with men (MSM) or transgender women (TGW) who are either living with HIV (PLHIV) or are receiving pre-exposure prophylaxis (PrEP), according to a study presented at AIDS 2022.

Why do psoriasis patients report better QoL amid COVID-19?
Patients with psoriasis report improved quality of life under the COVID-19 pandemic despite harsh movement restrictions, a recent study has found. Such an effect, however, may suggest that current tools do not completely capture the negative impacts of harsh lockdowns on patients’ wellbeing.

Brensocatib has no impact on COVID-19 clinical outcomes
Results of the STOP-COVID trial, presented at ERS 2022, showed no clinical outcome benefit with the dipeptidyl peptidase-1 (DPP-1) inhibitor brensocatib compared with placebo in patients hospitalized with COVID-19 in the UK.

Add-on, switch-to PEG-IFN therapy strategies improve serological response in CHB patients
Chronic hepatitis B (CHB) patients, who have virological response with long-term entecavir (ETV) treatment, appear to fare well with a strategy of adding or switching to peginterferon (PEG-IFN) therapy, as shown in a study.

Molnupiravir and nirmatrelvir/ritonavir show favourable hepatic safety in COVID-19 patients in HK
A territory-wide cohort study in Hong Kong shows favourable hepatic safety profile with the oral antivirals, molnupiravir and nirmatrelvir/ritonavir, in COVID-19 patients, including those at risk of drug-induced liver injury (DILI).


