Inborn errors of type 1 IFN immunity: An underlying cause of life-threatening COVID-19
20 Oct 2020
byDr Margaret Shi
Results of a recent immunology study by researchers at the University of Hong Kong (HKU), in alliance with the Coronavirus Disease 2019 (COVID-19) Human Genetic Effort (COVID HGE) international collaboration, reveal that inborn errors of type 1 interferon (IFN) immunity appear to be the underlying cause of life-threatening COVID-19, with titre and affinity enhanced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–driven induction of type 1 IFNs.