Early initiation of sacubitril/valsartan associated with better outcomes in heart failure
In patients with heart failure with reduced ejection fraction (HFrEF) hospitalized for acute decompensated HF (ADHF) who have achieved haemodynamic stability, early in-hospital initiation of the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan is associated with a significant reduction in HF rehospitalization or cardiovascular (CV) death compared with delayed initiation of sacubitril/valsartan after 8 weeks of enalapril treatment, a secondary analysis of the PIONEER-HF trial has shown.