News & Updates

Interim findings boost therapeutic potential of lanifibranor for NASH

06 Dec 2021 by

The pan-PPAR* agonist lanifibranor further advances into the NASH** treatment field, as more data from the phase IIb NATIVE*** study presented at AASLD 2021 unveil further histologic and therapeutic benefits for patients with NASH.

Interim findings boost therapeutic potential of lanifibranor for NASH

06 Dec 2021

PD-1 inhibitors outperform chemo in second-line treatment of advanced oesophageal cancer

06 Dec 2021

In the second-line treatment of patients advanced oesophageal cancer, the use of programmed cell death 1 (PD-1) inhibitors yields more favourable outcomes than chemotherapy across multiple patient subgroups, according to the results of a meta-analysis.

PD-1 inhibitors outperform chemo in second-line treatment of advanced oesophageal cancer

06 Dec 2021

Original New Drug Application Approvals by US FDA (16 - 30 November 2021)

06 Dec 2021

New drug applications approved by US FDA as of 16-30 November 2021 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16 - 30 November 2021)

06 Dec 2021

Canagliflozin improves HF symptoms, QoL regardless of diabetes status

04 Dec 2021 by

The SGLT2i* canagliflozin significantly improves symptoms and quality of life (QoL) early on during treatment in people with heart failure (HF) due to either reduced or preserved ejection fraction (rEF or pEF), regardless of whether they have type 2 diabetes (T2D), according to the CHIEF-HF** study presented at AHA 2021.

Canagliflozin improves HF symptoms, QoL regardless of diabetes status

04 Dec 2021

Actual body weight dosing of temozolomide offers survival benefits in glioblastoma

03 Dec 2021

Temozolomide administered to patients with glioblastoma at full actual body weight dosing during the concurrent phase is necessary to achieve a median overall survival (OS) that is similar to that seen in a previous trial, according to a recent study.

Actual body weight dosing of temozolomide offers survival benefits in glioblastoma

03 Dec 2021

Steroid-free remission in Crohn’s disease does not equate to less progression

03 Dec 2021

For Crohn’s disease patients, achieving a complete and sustained clinical remission off steroids does not necessarily translate to a lower likelihood of experiencing progression, according to data from the TAILORIX trial.

Steroid-free remission in Crohn’s disease does not equate to less progression

03 Dec 2021

Inclisiran sustains LDL-C reduction in high-risk patients with ASCVD

03 Dec 2021 by

Treatment with inclisiran consistently reduced low-density lipoprotein cholesterol (LDL-C) levels in patients with, or at high risk of, atherosclerotic cardiovascular disease (ASCVD), regardless of glycaemic status, based on a pooled analysis of the ORION-10* and ORION-11** studies presented at AHA 2021.

Inclisiran sustains LDL-C reduction in high-risk patients with ASCVD

03 Dec 2021

Milvexian prevents VTE after knee arthroplasty, bleeding risk low

02 Dec 2021 by

Postoperative treatment with the oral factor XIa inhibitor milvexian could help prevent the incidence of venous thromboembolism (VTE) in patients undergoing elective knee arthroplasty, according to results of a phase II trial presented at AHA 2021.

Milvexian prevents VTE after knee arthroplasty, bleeding risk low

02 Dec 2021

Two-dose hep-B vaccine more seroprotective than three-dose regimen in chronic liver disease patients

02 Dec 2021 by

In a pooled post hoc analysis of three phase III trials, a novel two-dose hepatitis B (hep-B) vaccine regimen trumped the traditional three-dose regimen in inducing seroprotection in patients with chronic liver disease (CLD).

Two-dose hep-B vaccine more seroprotective than three-dose regimen in chronic liver disease patients

02 Dec 2021

Does statin affect performance of PSA screening?

02 Dec 2021 by

Prostate-specific antigen (PSA) screening was associated with similar decrease in incidence of advanced prostate cancer (PCa) among statin users vs nonusers, but less detection of low-grade localized tumours in the former than the latter — indicating that statin does not compromise the benefits of PSA-based screening while also conferring the benefit of less overdiagnosis of low-risk tumours.

Does statin affect performance of PSA screening?

02 Dec 2021

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Interim findings boost therapeutic potential of lanifibranor for NASH

Interim findings boost therapeutic potential of lanifibranor for NASH

PD-1 inhibitors outperform chemo in second-line treatment of advanced oesophageal cancer

PD-1 inhibitors outperform chemo in second-line treatment of advanced oesophageal cancer

Original New Drug Application Approvals by US FDA (16 - 30 November 2021)

Original New Drug Application Approvals by US FDA (16 - 30 November 2021)

Canagliflozin improves HF symptoms, QoL regardless of diabetes status

Canagliflozin improves HF symptoms, QoL regardless of diabetes status

Actual body weight dosing of temozolomide offers survival benefits in glioblastoma

Actual body weight dosing of temozolomide offers survival benefits in glioblastoma

Steroid-free remission in Crohn’s disease does not equate to less progression

Steroid-free remission in Crohn’s disease does not equate to less progression

Inclisiran sustains LDL-C reduction in high-risk patients with ASCVD

Inclisiran sustains LDL-C reduction in high-risk patients with ASCVD

Milvexian prevents VTE after knee arthroplasty, bleeding risk low

Milvexian prevents VTE after knee arthroplasty, bleeding risk low

Two-dose hep-B vaccine more seroprotective than three-dose regimen in chronic liver disease patients

Two-dose hep-B vaccine more seroprotective than three-dose regimen in chronic liver disease patients

Does statin affect performance of PSA screening?

Does statin affect performance of PSA screening?