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Long-term exposure to ambient air pollution ups risk of pneumonia
Individuals with long-term exposure to air pollutants appear to be at higher risk of pneumonia, with the risk being more pronounced among smokers, as shown in a study.
Long-term exposure to ambient air pollution ups risk of pneumonia
24 Feb 2023VV116 noninferior to nirmatrelvir-ritonavir for COVID-19
Early administration of oral VV116 was noninferior to nirmatrelvir-ritonavir in shortening the time to sustained clinical recovery in individuals with mild-to-moderate COVID-19 who were at high risk for progression to severe disease, a phase III trial has shown. VV116 also had fewer safety issues than nirmatrelvir-ritonavir.
VV116 noninferior to nirmatrelvir-ritonavir for COVID-19
21 Feb 2023Gefitinib plus chemotherapy improves survival outcomes in mutated NSCLC brain metastases
Treatment with the combination of gefitinib and chemotherapy appears to yield significant increases in progression-free survival (PFS), intracranial PFS, and overall survival in patients with untreated EGFR-mutant non-small cell lung cancer (NSCLC) brain metastases as compared gefitinib monotherapy, according to the results of the phase III GAP BRAIN study.
Gefitinib plus chemotherapy improves survival outcomes in mutated NSCLC brain metastases
18 Feb 2023Childhood asthma, T1D, IBD: Do they have shared mechanisms?
Children diagnosed with asthma between ages 5 and 7 years may have an increased risk of developing type 1 diabetes (T1D) and inflammatory bowel diseases (IBD; Crohn’s disease and ulcerative colitis), a Danish nationwide registry study suggests.
Childhood asthma, T1D, IBD: Do they have shared mechanisms?
15 Feb 2023Risk model-based lung cancer screening more economical than USPSTF recommendation
Lung cancer screening based on a risk model is more cost-effective than the 2021 recommendation by the US Preventive Services Task Force (USPSTF), meriting further consideration for the former, reports a recent study.
Risk model-based lung cancer screening more economical than USPSTF recommendation
14 Feb 2023Shorter treatment regimen feasible for rifampin-resistant TB?
Individuals with rifampin-resistant tuberculosis (RR-TB) may have the option to undergo shorter treatment periods, as findings from the phase II/III TB-PRACTECAL* trial show the noninferiority and superiority of a 24-week, all-oral regimen to standard of care (SoC). It also had a better safety profile than SoC.
Shorter treatment regimen feasible for rifampin-resistant TB?
13 Feb 2023Is first-line lazertinib monotherapy a potential new SoC for EGFRm NSCLC?
Patients with EGFR-mutated (EGFRm) advanced non-small cell lung cancer (NSCLC) exhibited significantly improved progression-free survival (PFS) when treated with lazertinib compared with gefitinib in the first-line setting, results of the LASER301 trial showed.