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Adagrasib shows antitumour activity in KRAS G12C-mutant colorectal cancer
Adagrasib appears to have some effect against metastatic, KRAS G12C-mutated colorectal cancer when used in treatment-experienced patients either as oral monotherapy or in combination with cetuximab, according to the results of a phase I-II, open-label study.
Adagrasib shows antitumour activity in KRAS G12C-mutant colorectal cancer
07 Jan 2023Investigational antisense oligonucleotide for chronic HBV infection shows positive results
Treatment with the antisense oligonucleotide bepirovirsen appears to lead to sustained loss of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA in up to 10 percent of patients with chronic HBV infection, according to the results of the phase IIb study B-Clear.
Investigational antisense oligonucleotide for chronic HBV infection shows positive results
06 Jan 2023Procalcitonin-based algorithm reduces unnecessary antibiotic use in acute pancreatitis
A procalcitonin-guided algorithm could reduce the unnecessary use of antibiotics in patients with acute pancreatitis, according to results of the PROCAP trial.
Procalcitonin-based algorithm reduces unnecessary antibiotic use in acute pancreatitis
01 Jan 2023TACE + apatinib: A potential new strategy for intermediate/advanced HCC?
In patients with intermediate or advanced hepatocellular carcinoma (HCC), combining transarterial chemoembolization (TACE) with apatinib led to improvement in progression-free survival (PFS), according to a recent study from China.
TACE + apatinib: A potential new strategy for intermediate/advanced HCC?
28 Dec 2022Coeliac disease tied to higher risk of juvenile idiopathic, rheumatoid arthritis
Young patients with coeliac disease (CD) tend to develop juvenile idiopathic arthritis (JIA) three times more often than does the general population, while adult CD patients appear to have rheumatoid arthritis (RA) nearly twice as often, reveals a study.
Coeliac disease tied to higher risk of juvenile idiopathic, rheumatoid arthritis
26 Dec 2022FMT offers no weight loss benefits in individuals with obesity
For individuals with obesity who are scheduled to undergo bariatric surgery, faecal microbiota transplantation (FMT) from a lean donor does not appear to help reduce weight before or after the procedure, according to a study.
FMT offers no weight loss benefits in individuals with obesity
22 Dec 2022IBD study to shed light on how gut microbiota in pregnancy affects offspring
Researchers at the Chinese University of Hong Kong (CUHK) are recruiting pregnant women with inflammatory bowel disease (IBD), their newborns and spouse for a study to investigate how early-life exposure influences gut microbiota and IBD risk in the offspring, and to develop novel treatments for the increasingly prevalent condition.
IBD study to shed light on how gut microbiota in pregnancy affects offspring
22 Dec 2022Bepirovirsen shows promise in controlling chronic HBV infection
Weekly bepirovirsen treatment may help reduce HBsAg* and hepatitis B virus (HBV) DNA levels in patients with chronic HBV infection, the phase IIb B-Clear study showed.