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LNG-IUS use ups risk of depression
Use of a levonorgestrel-releasing intrauterine system (LNG-IUS) appears to increase the risk of incident depression, defined as initiation of an antidepressant or receipt of a depression diagnosis, in a dose-dependent manner, suggests a study.
Tenecteplase at 4.5–24 hours without thrombectomy feasible for ischaemic stroke
The use of tenecteplase in the extended time window of 4.5–24 hours improves functional outcomes in patients with ischaemic stroke when endovascular thrombectomy (EVT) is not immediately available, findings from the phase III TRACE-III* trial suggest.
Antidepressant nonresponders may benefit from rTMS
Repetitive transcranial magnetic stimulation (rTMS) demonstrates greater reduction in depressive symptoms than switching of antidepressant medications in patients with moderately treatment-resistant depression, reveals a study.
Ustekinumab biosimilar SB17 boasts similar efficacy, safety in psoriasis
SB17, a proposed ustekinumab (UST) biosimilar, demonstrates comparable efficacy, safety, and pharmacokinetics (PK) to the reference drug, as well as lower immunogenicity up to week 28, among individuals suffering from moderate-to-severe psoriasis, according to a study.
