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Original New Drug Application Approvals by US FDA (16 - 30 April 2022)

05 May 2022

New drug applications approved by US FDA as of 16-30 April 2022 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16 - 30 April 2022)

05 May 2022

Women with nonvalvular AF less likely to receive oral anticoagulation, at higher risk of stroke

04 May 2022

Female patients nonvalvular atrial fibrillation (AF) are less often prescribed guideline-recommended oral anticoagulation at the emergency department (ED), which in turn contributes to an increased stroke risk at 1 year regardless of discharge status, a study has found.

Women with nonvalvular AF less likely to receive oral anticoagulation, at higher risk of stroke

04 May 2022

New HF guideline: Quad therapy, HFmrEF, and more

04 May 2022 by

Hot on the heels of ACC.22 ground-breaking reports, the ACC/AHA/HFSA* released the 2022 heart failure (HF) guideline, with special emphasis on quad therapy for patients with reduced ejection fraction.

New HF guideline: Quad therapy, HFmrEF, and more

04 May 2022

Which DOAC is safest to use in AF patients on dronedarone therapy?

02 May 2022 by

Among patients on concomitant treatment with direct oral anticoagulants (DOACs) and dronedarone, no difference is seen in survival free from the composite endpoint (ie, clinically relevant bleeding, thromboembolic event, and all-cause death) and from clinically relevant bleeding between groups of coadministration, according to a study.

Which DOAC is safest to use in AF patients on dronedarone therapy?

02 May 2022

Sticking to a Mediterranean diet protects against pre-eclampsia

01 May 2022

Pregnant women with higher adherence to a Mediterranean‐style diet are at lower risk of pre-eclampsia, with the benefit observed among Black and White women, a study has found.

Sticking to a Mediterranean diet protects against pre-eclampsia

01 May 2022

Elevated lipoprotein(a) ups risk of atrial fibrillation

01 May 2022

Lipoprotein(a) (Lp[a]) appears to play a role in the development of atrial fibrillation (AF), with its effects extending across myocardial tissues, reveals a study.

Elevated lipoprotein(a) ups risk of atrial fibrillation

01 May 2022

Statins yields greater cardioprotection in women than men

30 Apr 2022

Treatment with statins is effective at lowering cardiovascular disease risk, with the protective effect seemingly stronger in women than in men, according to a study. However, high-intensity regimens confer only minimal additional benefit in both sexes.

Statins yields greater cardioprotection in women than men

30 Apr 2022

Exercise confers greater benefits in anxiety, depression

30 Apr 2022 by

The cardioprotective effects of exercise are nearly twice as large in people with anxiety and depression than in those without, suggests a new study presented at ACC.22.

Exercise confers greater benefits in anxiety, depression

30 Apr 2022

Bipolar ablation of heart arrhythmia safe, effective in lieu of failed unipolar approach

29 Apr 2022 by

Use of bipolar radiofrequency ablation (BRFA) is both safe and effective in selected patients who have failed at least one standard unipolar approach, suggest the results of a systematic review and meta-analysis. However, the quality of the supporting evidence is low.

Bipolar ablation of heart arrhythmia safe, effective in lieu of failed unipolar approach

29 Apr 2022

PDE5 inhibitor plus nitrates do not induce adverse events in IHD patients

29 Apr 2022

Use of phosphodiesterase type 5 (PDE5) inhibitors has increased 20-fold from 2000 to 2018, according to a study of Danish patients with ischaemic heart disease (IHD) who were taking nitrates. In addition, no statistically significant association has been observed between concomitant use of PDE5 inhibitors and cardiovascular adverse events.

PDE5 inhibitor plus nitrates do not induce adverse events in IHD patients

29 Apr 2022

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Original New Drug Application Approvals by US FDA (16 - 30 April 2022)

Original New Drug Application Approvals by US FDA (16 - 30 April 2022)

Women with nonvalvular AF less likely to receive oral anticoagulation, at higher risk of stroke

Women with nonvalvular AF less likely to receive oral anticoagulation, at higher risk of stroke

New HF guideline: Quad therapy, HFmrEF, and more

New HF guideline: Quad therapy, HFmrEF, and more

Which DOAC is safest to use in AF patients on dronedarone therapy?

Which DOAC is safest to use in AF patients on dronedarone therapy?

Sticking to a Mediterranean diet protects against pre-eclampsia

Sticking to a Mediterranean diet protects against pre-eclampsia

Elevated lipoprotein(a) ups risk of atrial fibrillation

Elevated lipoprotein(a) ups risk of atrial fibrillation

Statins yields greater cardioprotection in women than men

Statins yields greater cardioprotection in women than men

Exercise confers greater benefits in anxiety, depression

Exercise confers greater benefits in anxiety, depression

Bipolar ablation of heart arrhythmia safe, effective in lieu of failed unipolar approach

Bipolar ablation of heart arrhythmia safe, effective in lieu of failed unipolar approach

PDE5 inhibitor plus nitrates do not induce adverse events in IHD patients

PDE5 inhibitor plus nitrates do not induce adverse events in IHD patients