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Is adjunctive vitamin C beneficial to critically ill patients with COVID-19?
Use of adjunctive intravenous (IV) vitamin C for the management of critically ill patients with COVID-19 infection does not achieve the desired outcome of a reduction in the incidence of mortality, vasopressor requirements, Sequential Organ Failure Assessment (SOFA) scores, or ventilator settings, reports a study.

Fracture risk not higher with SGLT2 vs DPP4 inhibitors
The use of sodium-glucose transporter 2 (SGLT2) inhibitors among patients with diabetes does not pose an increased risk of developing fractures as compared with dipeptidyl-peptidase 4 (DPP4) inhibitors, and this is true across estimated glomerular filtration rate (eGFR) and albuminuria categories, as shown in a study.

Gefitinib plus chemotherapy improves survival outcomes in mutated NSCLC brain metastases
Treatment with the combination of gefitinib and chemotherapy appears to yield significant increases in progression-free survival (PFS), intracranial PFS, and overall survival in patients with untreated EGFR-mutant non-small cell lung cancer (NSCLC) brain metastases as compared gefitinib monotherapy, according to the results of the phase III GAP BRAIN study.

Immune-mediated reactions predict survival in nivolumab-treated NSCLC patients
Several patients with nonsmall cell lung cancer (NSCLC) treated with nivolumab report developing immune-related adverse events (irAEs), primarily affecting the skin, lungs, and gastrointestinal system, according to a study.





