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Sotorasib improves PFS over docetaxel in KRASG12C-mutated advanced NSCLC

15 Dec 2022 by

The first-in-class KRAS^G12C inhibitor sotorasib significantly improved progression-free survival (PFS) in patients with previously treated non-small cell lung cancer (NSCLC) with KRAS^G12C mutations, according to results of the phase III CodeBreaK 200 trial presented at ESMO 2022.

15 Dec 2022

Food interrupts absorption of diazepam nasal spray

15 Dec 2022

Food appears to affect the pharmacokinetics of diazepam dosed via nasal spray, with absorption being markedly decreased and delayed, according to an open-label crossover study.

15 Dec 2022

Oral testosterone undecanoate safe, effective in hypogonadal men

15 Dec 2022

Long-term treatment with an oral testosterone undecanoate (TU) formulation improves clinical outcomes in men with hypogonadism with no serious safety concerns, a study has shown.

15 Dec 2022

Targeted naltrexone eases binge drinking among sexual/gender minority men

15 Dec 2022 by

Targeted oral naltrexone results in a significant reduction in drinking outcomes among sexual and gender minority men (SGM) with mild to moderate alcohol use disorder (AUD) during treatment, reports a study. This beneficial effect persists up to 6 months post-treatment.

15 Dec 2022

ALXN1840 generates rapid, sustained copper mobilization in Wilson disease

15 Dec 2022 by

In individuals with Wilson disease (WD), a rare disease of copper metabolism, ALXN1840 led to significantly greater copper mobilization compared with standard of care (SoC), findings from a rater-blinded phase III study have shown.

15 Dec 2022

Upadacitinib rapidly effective in ulcerative colitis

15 Dec 2022

Treatment with upadacitinib appears to produce improvements in ulcerative colitis (UC) symptoms as early as day 1, as shown in a recent study.

15 Dec 2022

Antirheumatic drugs confer cardioprotection, too

14 Dec 2022 by

Treatments used in rheumatoid arthritis, called disease-modifying antirheumatic drugs, can also lower the risk of heart disease among patients, as shown in a recent study.

14 Dec 2022

Prophylactic G-CSF averts febrile neutropaenia in docetaxel-treated breast cancer patients

14 Dec 2022

Prophylactic granulocyte-colony stimulating factor (G-CSF) results in a significant decrease both in the rate of febrile neutropaenia (FN) and duration of hospitalization for FN in breast cancer patients treated with docetaxel-based chemotherapy regimens (DBRs), according to a recent study.

14 Dec 2022

Post hoc data boost voclosporin efficacy for severe lupus nephritis

14 Dec 2022 by

In the post hoc analysis of the AURORA 1 and 2 trials, the novel calcineurin inhibitor voclosporin was effective in achieving complete renal response (CRR)* in individuals with severe lupus nephritis** (LN).

14 Dec 2022

Palbociclib–bazedoxifene combo for HR+/HER2− breast cancer succeeds in early trial

14 Dec 2022

Treatment with the combination of palbociclib plus bazedoxifene demonstrates clinical efficacy while having an acceptable safety profile in treatment-experienced patients with hormone receptor–positive/HER2-negative (HR+/HER2−) advanced breast cancer, according to the results of a phase Ib/II study.

14 Dec 2022

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Sotorasib improves PFS over docetaxel in KRASG12C-mutated advanced NSCLC

Food interrupts absorption of diazepam nasal spray

Oral testosterone undecanoate safe, effective in hypogonadal men

Targeted naltrexone eases binge drinking among sexual/gender minority men

ALXN1840 generates rapid, sustained copper mobilization in Wilson disease

Upadacitinib rapidly effective in ulcerative colitis

Antirheumatic drugs confer cardioprotection, too

Prophylactic G-CSF averts febrile neutropaenia in docetaxel-treated breast cancer patients

Post hoc data boost voclosporin efficacy for severe lupus nephritis

Palbociclib–bazedoxifene combo for HR+/HER2− breast cancer succeeds in early trial