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MDT without ADT delays systemic therapy initiation in recurrent prostate cancer
In patients with solitary metastatic recurrences of prostate cancer, metastasis-directed therapy (MDT without androgen deprivation therapy (ADT) can lead to delayed initiation of systemic therapy, according to a study.

Biologics prevent infection-related hospitalization in IBD patients with comorbidity
Treatment with vedolizumab or ustekinumab leads to reduced rates of infection-related hospitalization compared with antitumour necrosis factor-α antagonists (anti-TNF) among adults with inflammatory bowel disease (IBD) initiating biologic therapy and with high comorbidity burden, reports a recent study.

High-flow oxygen does not reduce mortality in COVID-19 respiratory failure
The use of high-flow nasal cannula oxygen, as opposed to standard oxygen, in the first-line setting, did not reduce mortality rates in patients admitted to intensive care units (ICUs) for respiratory failure due to COVID-19, results of the SOHO-COVID trial showed.

CRT vs SBRT: Which approach yields better outcomes in PDAC?
Multiagent chemotherapy (MAC) followed by conventionally fractionated radiotherapy (CRT) shows rates of margin-negative resection (R0) and pathologic complete response similar to those of MAC plus stereotactic body radiotherapy (SBRT) in patients with localized pancreatic ductal adenocarcinoma (PDAC), according to a study. However, MAC plus CRT is associated with less regional lymphatic disease.





