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Combined oral contraceptives and VTE: Which pill conveys the highest risk in young women?
Combined oral contraceptives (COCs) that contain gestodene confer a fivefold increased risk of venous thromboembolism (VTE) in young women as compared with those that contain levonorgestrel and the lowest doses of ethinylestradiol, as shown in a study.

Add-on pembrolizumab–tocilizumab combo reduces hospitalization period in severe COVID-19
In the treatment of patients with severe COVID-19, adding the combination of pembrolizumab plus tocilizumab to standard of care (SOC) appears to result in higher and faster discharge from the hospital without sequelae, as shown in the proof-of-concept phase II COPERNICO trial.

Dulaglutide safely controls glucose in T2D with CKD
In patients with type 2 diabetes (T2D) with chronic kidney disease (CKD), once-weekly dosage with dulaglutide achieves adequate glycaemic control along with a reduced decline in estimated glomerular filtration rate (eGFR), reports a recent study.

Early transition to oral antimicrobials prevents treatment failure in children with SAB, AHO
Children with Staphylococcus aureus bacteraemia (SAB), a common complication of acute hematogenous osteomyelitis (AHO), are vulnerable to a wide range of illnesses, suggests a study. Thus, classifying its severity may aid in treatment decision-making.

Adjuvant sorafenib after RFA boosts survival in recurrent hepatocellular carcinoma
The use of sorafenib as an adjuvant therapy after radiofrequency ablation (RFA) appears to improve survival outcomes in patients with recurrent hepatocellular carcinoma who underwent hepatectomy, according to a study.

Pimavanserin trumps atypical antipsychotics in preventing death in Parkinson’s disease patients
Use of pimavanserin appears to be more effective than atypical antipsychotic agents in reducing mortality among Parkinson’s disease patients during the first 180 days of treatment, reveals a study. However, such benefit is seen only in community-dwelling patients and not in nursing home residents.



