News & Updates

Using the probiotic Escherichia coli Nissle 1917 (EcN) as add-on therapy for patients with mild-to-moderate ulcerative colitis (UC) helps induce disease remission and preserve quality of life (QoL) in these patients, according to studies presented at CCC 2022.

REL-1017 (esmethadone), a novel N-methyl-D-aspartate receptor channel blocker, demonstrates favourable safety, tolerability, and pharmacokinetic profiles and appears to have rapid and sustained antidepressant effects relative to placebo in major depressive disorder patients with inadequate responses to antidepressant treatments, according to a recent study.

In individuals with progressive locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC), the VEGFR-2* inhibitor apatinib demonstrated significant clinical benefits in terms of progression-free survival (PFS) and overall survival (OS), with a manageable safety profile, findings from the phase III REALITY trial suggest.

The oral selective inhibitor of exportin-1 (XPO1) selinexor has therapeutic potential in recurrent glioblastoma, yielding favourable responses and clinically relevant 6-month progression-free survival (PFS) rate with manageable side effects requiring dose reductions, according to the results of a phase II trial.

New drug applications approved by US FDA as of 16-31 January 2022 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

The addition of mogamulizumab to nivolumab falls short of improving efficacy of the latter in the treatment of patients with locally advanced or metastatic solid tumours, according to the results of a phase I/II trial.

In the management of virologically suppressed patients living with HIV, efavirenz 400 mg has noninferior efficacy and favourable safety as compared with the 600 mg-based regimen, according to a study from China.

Treatment with topical recombinant human nerve growth factor (rhNGF) is safe and well tolerated but falls short of providing neuroprotection in patients with glaucoma, according to the results of a phase Ib study.