News &amp; Updates

The use of radiofrequency ablation of the vaginal canal by the MorpheusV applicator helps reduce symptoms of genitourinary syndrome of menopause (GSM), which include burning, dryness, dyspareunia, and irritative lower urinary tract symptoms, according to a study.

Radiofrequency ablation of vaginal canal relieves GSM symptoms

Metformin may reduce asthma attacks

The glucose-lowering drug metformin appears to be associated with fewer asthma attacks, with further reductions when metformin is used in combination with GLP-1RAs, according to a study.

Metformin may reduce asthma attacks

Consolidative stem cell transplant may be skipped for MCL patients with undetectable disease

11 Jan 2025 by

In patients with mantle cell lymphoma (MCL) who have achieved complete remission and undetectable minimal residual disease (MRD) following initial therapy, autologous hematopoietic cell transplantation (auto-HCT) confers no survival advantage when compared with maintenance therapy alone, as shown in the interim results of the phase III ECOG-ACRIN EA4151 trial.

Consolidative stem cell transplant may be skipped for MCL patients with undetectable disease

Ustekinumab levels higher in IBD patients with normal CRP, endoscopic healing

Patients with inflammatory bowel disease (IBD) who achieve a normal C-reactive protein (CRP) and endoscopic healing exhibit significantly higher ustekinumab trough levels, reveals a study. A cutoff level of 4.8 µg/mL predicts CRP normalization.

Ustekinumab levels higher in IBD patients with normal CRP, endoscopic healing

Anti-CGRP monoclonal antibodies pose no increased CVD risk

Monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) or its receptor do not appear to contribute to heightened risk of cardiovascular disease (CVD) relative to onabotulinumtoxinA in adults with migraine at high CVD risk, according to a study.

Anti-CGRP monoclonal antibodies pose no increased CVD risk

Active monitoring safe for low-risk ductal carcinoma in situ

Among women with low-risk ductal carcinoma in situ, the incidence of invasive cancer in the same breast does not appear to be different between those who have undergone active monitoring and those who have received a surgical procedure, according to the results of COMET trial.

Active monitoring safe for low-risk ductal carcinoma in situ

Cirrhosis, portal hypertension worsen bowel prep for colonoscopy

A recent study has observed poorer Boston Bowel Preparation Scale (BBPS) scores and longer cecal intubation times in patients with cirrhosis undergoing screening colonoscopy. Those who are not obese also have a lower rate of polyp detection.

Cirrhosis, portal hypertension worsen bowel prep for colonoscopy

Blinatumomab plus chemo improves survival in paediatric B-ALL

Chemotherapy combined with blinatumomab (blin) delivers significant improvements in disease-free survival (DFS) in children with newly diagnosed National Cancer Institute standard risk (SR) B-cell acute lymphoblastic leukaemia (B-ALL), according to the results of the AALL1731 study presented at ASH 2024.

Blinatumomab plus chemo improves survival in paediatric B-ALL

Tafasitamab plus lenalidomide, rituximab boosts PFS in follicular lymphoma

The addition of tafasitamab (tafa) to lenalidomide and rituximab (len+R) significantly improves progression-free survival (PFS) in patients with relapsed or refractory (R/R) follicular lymphoma (FL), as shown in a phase III study presented at ASH 2024. The safety profile of this combination is manageable and consistent with expected toxicities.

Tafasitamab plus lenalidomide, rituximab boosts PFS in follicular lymphoma

Survival benefit with STRIDE for HCC sustained at 5 years