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COVID outcomes worse in polluted cities

01 Jul 2023 by

More evidence suggests that people exposed to more air pollution during the pandemic are at greater risk for COVID-19 infection, hospitalization, and death, but the exact mechanism behind the link is unknown.

01 Jul 2023

DOACs as good as LMWH for recurrent VTE prevention in cancer patients

29 Jun 2023

For patients with cancer who have recurrent venous thromboembolism (VTE), direct oral anticoagulants (DOACs) compare favourably with low-molecular-weight heparin (LMWH) in terms of recurrence prevention, according to a study.

29 Jun 2023

Hypertension tied to weakened ventilatory efficiency

27 Jun 2023

Hypertensive individuals without a diagnosis of heart failure appear to have impaired ventilatory efficiency, which reflects an abnormal physiological response to exercise, according to a study.

27 Jun 2023

Gliosis may explain depressive or cognitive symptoms after COVID

22 Jun 2023 by

Patients with persistent depressive or cognitive symptoms after an acute SARS-CoV-2 infection have elevated gliosis – a secondary event to brain injury – and inflammation as shown in a case-control study.

22 Jun 2023

COVID-19 oral antivirals reduce hospitalization and inpatient progression in nursing home residents

21 Jun 2023 by

A territory-wide, retrospective cohort study in Hong Kong has shown that molnupiravir and nirmatrelvir/ritonavir are effective in reducing the risks of hospitalization and inpatient disease progression among older patients residing in nursing homes.

21 Jun 2023

Updated CodeBreak 200 analyses boost sotorasib role in KRASG12C-mutant NSCLC

19 Jun 2023 by

In the PRO analyses of the phase III CodeBreak 200 trial, the first-in-class KRAS^G12C inhibitor sotorasib improved quality of life (QoL) of patients with pretreated KRAS^G12C-mutated advanced non-small-cell lung cancer (NSCLC) compared with docetaxel.

19 Jun 2023

Hint of benefit with antifibrotic treatment seen for interstitial lung disease

16 Jun 2023

Antifibrotic treatment appears to put brakes on the decline of lung function, as evidenced by forced vital capacity (FVC) measurements, in patients with interstitial lung disease (ILD) related to connective tissue disease (CTD) or rheumatoid arthritis (RA), according to a study.

16 Jun 2023

BNT162b2 booster protects against COVID-19 infection, hospitalization in adolescents

13 Jun 2023 by

In a national cohort study in Singapore, a booster dose of BNT162b2 maintained individual protection against severe COVID-19 disease among adolescents aged 12–17 years.

13 Jun 2023

Bivalent mRNA-1273.214 vaccine safe, immunogenic in children

13 Jun 2023 by

Interim results from the ongoing Study 306, a phase III open-label trial, show improved immunogenicity and safety of the bivalent Omicron-containing mRNA-1273.214 vaccine in children 6 months to 5 years of age, both as a primary series and a booster.

13 Jun 2023

Perioperative durvalumab-based regimen improves outcomes in resectable NSCLC

12 Jun 2023 by

In individuals with resectable non-small-cell lung cancer (NSCLC), the addition of perioperative durvalumab to neoadjuvant chemotherapy improved pathologic complete response (pCR) and event-free survival (EFS), findings from the AEGEAN study have shown.

12 Jun 2023