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Nirmatrelvir conferred protection in older adults during the Omicron outbreak
During the surge of the Omicron (B.1.1.529) variant, antiviral therapy with nirmatrelvir significantly reduced the rate of COVID-19-related hospitalization or death among patients aged ≥65 years, according to a recent study.

3D-printed masks a good alternative to N95 respirators
Reusable 3D-printed respirators offer a cost-effective alternative to N95 masks in providing protection against respiratory pathogens, such as SARS-CoV-2, suggests a recent study. In addition, fit testing results show that some 3D-printed mask designs appear to exceed the fit of N95 masks.

CROWN: 1L lorlatinib improves PFS, reduces CNS progression in ALK-positive NSCLC ± brain metastases
First-line treatment of ALK-positive non-small-cell lung cancer (NSCLC) with lorlatinib improves progression-free survival (PFS) and reduces central nervous system (CNS) progression vs crizotinib, regardless of presence or absence of baseline brain metastases (BM), a post hoc analysis of the phase III CROWN trial has shown.

Could tixagevimab–cilgavimab prevent progression to severe COVID-19 in unvaccinated adults?
The combination of tixagevimab and cilgavimab, two SARS-CoV-2 neutralizing monoclonal antibodies, appeared to protect against progression to severe disease or death in non-hospitalized, unvaccinated adults presenting with mild-to-moderate COVID-19, results of the ongoing phase III TACKLE trial showed.

ILD incidence rare in SLE patients, linked to death
Interstitial lung disease (ILD) rarely occurs in patients with systemic lupus erythematosus (SLE), but when it does, ILD is often associated with other systemic autoimmune disorders and may even significantly contribute to mortality, according to a study.

Hypocalcaemia tied to mid-, long-term death in acute pulmonary thromboembolism
Low serum calcium in patients with acute pulmonary thromboembolism (PTE) independently predicts 30-day and long-term mortality, suggests a China study that used a new prognosis assessment model.


