News &amp; Updates

The use of granulocyte colony-stimulating factors (GCSFs) as primary prophylaxis (PP) reduces the incidence of febrile neutropenia (FN) and associated hospitalization among breast cancer patients receiving docetaxel-containing chemotherapy, with 4–5 days of PP offering similar efficacy and greater healthcare expenditure savings vs 7-day PP, results of a retrospective cohort study in Hong Kong have shown.

GCSF primary prophylaxis reduces febrile neutropenia and hospitalization in docetaxel-treated breast cancer patients

Comorbidities flag poor outcome on vedolizumab, ustekinumab for IBD

In the treatment of patients with inflammatory bowel disease (IBD), comorbidities, but not patient age, influence the risk of any infection or hospitalizations on either vedolizumab or ustekinumab, a study suggests.

Comorbidities flag poor outcome on vedolizumab, ustekinumab for IBD

Migraine is no small matter when one looks into the economic loss associated with it.

While headaches and migraines may seem trivial, they are major causes of absenteeism and loss of productivity in the workplace, studies reveal.

Migraine is no small matter when one looks into the economic loss associated with it.

Lorecivivint for knee OA unsuccessful in phase IIa trial

The novel Wnt pathway modulator lorecivivint does not appear to be effective for treating pain and inhibiting structural progression in moderate-to-severe knee osteoarthritis (OA), according to the results of a phase IIa trial.

Lorecivivint for knee OA unsuccessful in phase IIa trial

Mental illness could worsen COVID-19 severity

Diagnosis of mental illness is not associated with an increased likelihood of testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but of an increased risk of severe illness from coronavirus disease 2019 (COVID-19) compared with patients without metal illness, results of a recent study in South Korea have shown.

Mental illness could worsen COVID-19 severity

SSRI use tied to small increase in diabetes risk among children and adolescents

Children and adolescents initiating selective serotonin reuptake inhibitor (SSRI) treatment may have a small increase in risk of developing type 2 diabetes mellitus (T2DM), particularly among publicly insured patients, results of a recent study have shown.

SSRI use tied to small increase in diabetes risk among children and adolescents

Pembrolizumab + chemo emerging as first-line SoC in advanced oesophageal cancer

Pembrolizumab in combination with chemotherapy significantly improves overall survival (OS), progression-free survival (PFS) and objective response rate (ORR) vs chemotherapy alone in patients with previously untreated, locally advanced unresectable or metastatic oesophageal cancer, according to results of the phase III KEYNOTE-590 study presented at the European Society for Medical Oncology (ESMO) Virtual Congress 2020.

Pembrolizumab + chemo emerging as first-line SoC in advanced oesophageal cancer

Serum assessment detects nonadherence to adjuvant tamoxifen in early breast cancer

Serum assessment of drug level may detect early nonadherence to adjuvant tamoxifen therapy and identify patients with early breast cancer at risk of poorer outcomes, new data from the CANTO study have shown.

Serum assessment detects nonadherence to adjuvant tamoxifen in early breast cancer

Severe amino acid loss seen in patients on extracorporeal haemodialysis

Patients on high-efficiency haemodialysis and haemodiafiltration suffer from severe loss of non-essential and essential amino acids, a recent study has found.

Severe amino acid loss seen in patients on extracorporeal haemodialysis

Erectile dysfunction in healthy men more likely related to depression than MetS

Erectile dysfunction is quite common among apparently healthy men, and this is more likely to be related to depressive symptoms rather than metabolic syndrome (MetS), a study has found.

Erectile dysfunction in healthy men more likely related to depression than MetS