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SMAD7 overexpression boosts EGFR-CAR-T function against NSCLC
Epidermal growth factor receptor (EGFR)-mothers against decapentaplegic homologue 7 (SMAD7)-Chimeric antigen receptor (CAR) T-cell therapy against nonsmall-cell lung cancer (NSCLC) is on a par with EGFR-dominant‒negative transforming growth factor (TGFbeta) receptor 2 (DNR)-CAR-T in terms of efficacy and resistance to negative TGFβ regulation, a study has shown.
SMAD7 overexpression boosts EGFR-CAR-T function against NSCLC
10 Sep 2023
Airflow limitation predicts muscle wasting in COPD patients
Severe airflow limitation tends to contribute to future muscle wasting in patients with chronic obstructive pulmonary disease (COPD) and ever-smokers at risk of COPD, reports a recent study.
Airflow limitation predicts muscle wasting in COPD patients
09 Sep 2023
Hydrocortisone cuts mortality risk in ICU patients with severe pneumonia
In patients admitted to the intensive care unit (ICU) for severe community-acquired pneumonia (CAP), those who received hydrocortisone had a lower mortality risk compared with those on placebo, findings from the CAPE COD* trial suggest.
Hydrocortisone cuts mortality risk in ICU patients with severe pneumonia
08 Sep 2023
Severe bronchiolitis in infancy tied to reduced lung function in childhood
Infants with severe bronchiolitis are at heightened risk of having decreased lung function at age 6 years, according to a study.
