News & Updates

Use of sofosbuvir-based direct-acting antiviral regimens for treating hepatitis C virus (HCV) in clinical trial participants with chronic kidney disease (CKD) does not appear to worsen estimated glomerular filtration rate levels, according to a study. Furthermore, the drug does not appear to contribute to an increased risk of end-stage renal disease among HCV patients with CKD treated in clinical practice.

Polypharmacy (PP) arises in nearly one in five patients with inflammatory bowel disease (IBD), particularly in older adults and those with comorbidity, according to a study, adding that PP can complicate adherence to treatment and therapeutic success.

In men with erectile dysfunction (ED), adjuvant daily oral therapy with L-arginine and tadalafil was effective and safe in enhancing the efficacy and duration of benefits of low-intensity extracorporeal shockwave therapy (Li-ESWT), a study has shown.

In the treatment of patients with psoriasis, the combination of adalimumab plus methotrexate is more beneficial than adalimumab alone, reducing antidrug antibody formation and inducing slightly better response, drug survival, and higher serum trough concentrations, according to a study.

Tramadol exposure during early pregnancy does not appear to contribute to an increased risk of spontaneous abortion or congenital malformations, a study reports.

The prostaglandin D2 receptor 2 (DP2) antagonist GB001 does not appear to significantly lower the risk of disease worsening in patients with moderate-to-severe eosinophilic asthma, according to data from a phase IIb trial.

Individuals exposed to high cumulative doses of proton pump inhibitors (PPIs) have a slightly elevated risk of pancreatic cancer, a study reports.