News & Updates

True North: Ozanimod benefits in ulcerative colitis evident in various populations

21 Dec 2021 by

A post hoc analysis of the phase III True North study showed that the benefits of ozanimod on clinical remission and response in patients with moderate-to-severe ulcerative colitis (UC) as seen in the global analysis were consistent in the analysis of the North American cohort.

True North: Ozanimod benefits in ulcerative colitis evident in various populations

21 Dec 2021

Sleeve gastrectomy vs gastric bypass for weight loss: Which is safer?

21 Dec 2021 by

Sleeve gastrectomy was associated with a lower risk of mortality and complications over 5 years compared with gastric bypass, although the former intervention comes with an increased risk of surgical revision, reveals a recent study on patients undergoing bariatric surgery for weight loss.

Sleeve gastrectomy vs gastric bypass for weight loss: Which is safer?

21 Dec 2021

Hypotension prevents boosting of sacubitril/valsartan doses for Asians with ACHD-related HF

21 Dec 2021 by

The angiotensin receptor-neprilysin inhibitors (ARNI) sacubitril/valsartan does not appear to help manage heart failure (HF) in Asian patients with adult congenital heart disease (ACHD), with a small study from Singapore showing that the drug can only be tolerated at suboptimal doses and that hypotension prevents uptitration.

Hypotension prevents boosting of sacubitril/valsartan doses for Asians with ACHD-related HF

21 Dec 2021

Is continuous infusion labetalol haemodynamically safe for type B aortic dissections?

21 Dec 2021

Treatment with high-dose continuous intravenous labetalol (HD-CIVL) results in a nonstatistically significant higher incidence of haemodynamic instability compared to an esmolol combination (EC) regimen in patients with type B aortic dissections (TBADs), results of a study have shown.

Is continuous infusion labetalol haemodynamically safe for type B aortic dissections?

21 Dec 2021

TAF useful in pregnant women with chronic hepatitis B infection

20 Dec 2021

Treatment with tenofovir alafenamide (TAF) for pregnant women with active chronic hepatitis B (CHB) infection, when administered throughout or initiated early in pregnancy, is effective and safe in both mothers and infants, according to a study.

TAF useful in pregnant women with chronic hepatitis B infection

20 Dec 2021

Antithyroid drug therapy in pregnant women poses modest risk of congenital anomalies

20 Dec 2021

Exposure to thionamide antithyroid drugs (ATDs) during pregnancy contributes to a small increase in the risk of congenital anomalies, according to the results of a systematic review and meta-analysis.

Antithyroid drug therapy in pregnant women poses modest risk of congenital anomalies

20 Dec 2021

Coffee good – or bad – for the heart

20 Dec 2021 by

Daily coffee intake is tied to increased physical activity and incidence of premature ventricular contractions (PVCs) but fewer episodes of supraventricular tachycardia (SVT) and less nighttime sleep in the CRAVE* trial.

Coffee good – or bad – for the heart

20 Dec 2021

Original New Drug Application Approvals by US FDA (01-15 December 2021)

19 Dec 2021

New drug applications approved by US FDA as of 01-15 December 2021 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (01-15 December 2021)

19 Dec 2021

Pfizer's COVID-19 antiviral pills yield EPIC results for hospitalization, deaths

19 Dec 2021 by

A new oral COVID-19 antiviral therapy comprising nirmatrelvir and ritonavir substantially slashes the risk of hospitalization or death compared with placebo in nonhospitalized adults with COVID-19 who are at high risk of developing severe illness, according to final analysis of the EPIC-HR* study.

Pfizer's COVID-19 antiviral pills yield EPIC results for hospitalization, deaths

19 Dec 2021

Tadalafil plus antihypertensives yield no excess risk of hypotension, cardiac events

18 Dec 2021

The use of tadalafil with antihypertensive medications does not seem to cause an excess risk of hypotensive or cardiovascular outcomes in men with erectile dysfunction (ED), a recent real-world study has found.

Tadalafil plus antihypertensives yield no excess risk of hypotension, cardiac events

18 Dec 2021

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True North: Ozanimod benefits in ulcerative colitis evident in various populations

True North: Ozanimod benefits in ulcerative colitis evident in various populations

Sleeve gastrectomy vs gastric bypass for weight loss: Which is safer?

Sleeve gastrectomy vs gastric bypass for weight loss: Which is safer?

Hypotension prevents boosting of sacubitril/valsartan doses for Asians with ACHD-related HF

Hypotension prevents boosting of sacubitril/valsartan doses for Asians with ACHD-related HF

Is continuous infusion labetalol haemodynamically safe for type B aortic dissections?

Is continuous infusion labetalol haemodynamically safe for type B aortic dissections?

TAF useful in pregnant women with chronic hepatitis B infection

TAF useful in pregnant women with chronic hepatitis B infection

Antithyroid drug therapy in pregnant women poses modest risk of congenital anomalies

Antithyroid drug therapy in pregnant women poses modest risk of congenital anomalies

Coffee good – or bad – for the heart

Coffee good – or bad – for the heart

Original New Drug Application Approvals by US FDA (01-15 December 2021)

Original New Drug Application Approvals by US FDA (01-15 December 2021)

Pfizer's COVID-19 antiviral pills yield EPIC results for hospitalization, deaths

Pfizer's COVID-19 antiviral pills yield EPIC results for hospitalization, deaths

Tadalafil plus antihypertensives yield no excess risk of hypotension, cardiac events

Tadalafil plus antihypertensives yield no excess risk of hypotension, cardiac events