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Adalimumab–methotrexate combo better than adalimumab monotherapy in psoriasis
In the treatment of patients with psoriasis, the combination of adalimumab plus methotrexate is more beneficial than adalimumab alone, reducing antidrug antibody formation and inducing slightly better response, drug survival, and higher serum trough concentrations, according to a study.
Adalimumab–methotrexate combo better than adalimumab monotherapy in psoriasis
14 Mar 2022
Pregnancies exposed to tramadol not at heightened risk of miscarriage, congenital malformations
Tramadol exposure during early pregnancy does not appear to contribute to an increased risk of spontaneous abortion or congenital malformations, a study reports.
Pregnancies exposed to tramadol not at heightened risk of miscarriage, congenital malformations
14 Mar 2022
Investigational DP2 antagonist strikes out in eosinophilic asthma
The prostaglandin D2 receptor 2 (DP2) antagonist GB001 does not appear to significantly lower the risk of disease worsening in patients with moderate-to-severe eosinophilic asthma, according to data from a phase IIb trial.
Investigational DP2 antagonist strikes out in eosinophilic asthma
13 Mar 2022
Vitamin D deficiency tied to severe COVID-19
A systematic review and meta-analysis of >8,000 adult and elderly patients with COVID-19 showed a positive association between vitamin D deficiency (ie, 25(OH)D <50 nmol/L) and severe COVID-19.
Vitamin D deficiency tied to severe COVID-19
13 Mar 2022
Thyroid hormones help predict cardiogenic shock risk in STEMI patients post-PCI
Free triiodothyronine (FT3) and free thyroxine (FT4) independently predict in-hospital cardiogenic shock (CS) incidence among patients with ST-segment elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI), reports a recent study.