News & Updates

SARS-CoV-2 Variants: Everything you need to know

01 Feb 2023

The COVID-19 pandemic continues to evolve with the emergence of new SARS-CoV-2 variants. The variants of concern have the potential to impact the transmissibility, virulence, and clinical presentation of the disease, affecting the epidemiology, public health measures, and diagnostic and therapeutic options. Mutations in the spike protein of the virus have increased its ability to infect humans and evade neutralization by natural or immunisation-induced antibodies. The highly mutated Omicron variant of SARS-CoV-2 has multiple sublineages with varying transmissibility and immune evasion potential. Pre-exposure prophylaxis plays a crucial role in protecting the immunocompromised populations against severe disease; however, the rapidly changing landscape of the variants poses a major challenge to the current and future effectiveness of pre-exposure prophylactic monoclonal antibodies.

SARS-CoV-2 Variants: Everything you need to know

01 Feb 2023

Tumour response-speed heterogeneity linked to poor survival in metastatic colorectal cancer

01 Feb 2023

Tumour response-speed heterogeneity to first-line chemotherapy is predictive of early disease progression and shorter survival in patients with metastatic colorectal cancer, reveals a study.

Tumour response-speed heterogeneity linked to poor survival in metastatic colorectal cancer

01 Feb 2023

Circulating 11-oxygenated androgens predict survival in localized prostate cancer

01 Feb 2023 by

In men with localized prostate cancer undergoing radical prostatectomy and treated with 5α-reductase inhibitor (5-ARI), preoperative levels of circulating 11-oxygenated androgens can indicate either disease progression or improved survival, a recent study has found.

Circulating 11-oxygenated androgens predict survival in localized prostate cancer

01 Feb 2023

Starting dose of CDK4/6 inhibitors linked to survival in metastatic breast cancer

30 Jan 2023

Progression-free (PFS) and overall survival (OS) are similar between age groups (≥70 and <70 years) among patients treated with cyclin-dependent kinase (CDK) 4/6 inhibitors from 2015 to 2019, with no significant differences in neutropaenia or thrombocytopaenia toxicity, reports a study.

Starting dose of CDK4/6 inhibitors linked to survival in metastatic breast cancer

30 Jan 2023

Early-onset fever tied to severe cytokine release syndrome, multiple tocilizumab doses

29 Jan 2023

An earlier onset of fever appears to predict a more severe and progressive cytokine release syndrome, a life-threatening hyper-inflammatory state caused by immune effector cell therapy, suggests a study. Such condition also warrants several doses of anti-interleukin (IL)-6 therapy, such as tocilizumab.

Early-onset fever tied to severe cytokine release syndrome, multiple tocilizumab doses

29 Jan 2023

Pharmacist-led intervention improves BP control of patients on oral chemotherapy

28 Jan 2023

Patients on oral chemotherapy, who underwent a pharmacist-led hypertension management program, show improvements in blood pressure (BP) control as well as lower mean BP readings over time, reports a recent study.

Pharmacist-led intervention improves BP control of patients on oral chemotherapy

28 Jan 2023

Proton therapy reirradiation confers survival benefits in head and neck cancer, with caveat

27 Jan 2023

Treatment with proton therapy reirradiation for head and neck cancer appears to improve survival outcomes in patients, but this benefit comes with substantial toxic effects, according to a study.

Proton therapy reirradiation confers survival benefits in head and neck cancer, with caveat

27 Jan 2023

$Low BMD, fracture risk upped in childhood cancer survivors$

Low BMD, fracture risk upped in childhood cancer survivors

25 Jan 2023 by

Childhood cancer survivors (CCS) appear to have an increased risk of low bone mineral density (BMD) and fracture compared with the general population, according to a cross-sectional study from the Netherlands.

Low BMD, fracture risk upped in childhood cancer survivors

25 Jan 2023

Immune checkpoint inhibitors carry some risk of hepatotoxicity

25 Jan 2023

The use of immune checkpoint inhibitors (ICIs) for the treatment of various cancers appears to have hepatotoxic effects, the risk of which is greater with ICI combination therapy than with monotherapy, as reported in a recent study.

Immune checkpoint inhibitors carry some risk of hepatotoxicity

25 Jan 2023

Objective response to systemic therapy linked to overall survival in unresectable HCC

23 Jan 2023 by

Objective response to first-line systemic therapy with lenvatinib or sorafenib independently predicts overall survival (OS) in individuals with unresectable hepatocellular carcinoma (HCC), as shown by the subanalysis of the REFLECT study.

Objective response to systemic therapy linked to overall survival in unresectable HCC

23 Jan 2023

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SARS-CoV-2 Variants: Everything you need to know

SARS-CoV-2 Variants: Everything you need to know

Tumour response-speed heterogeneity linked to poor survival in metastatic colorectal cancer

Tumour response-speed heterogeneity linked to poor survival in metastatic colorectal cancer

Circulating 11-oxygenated androgens predict survival in localized prostate cancer

Circulating 11-oxygenated androgens predict survival in localized prostate cancer

Starting dose of CDK4/6 inhibitors linked to survival in metastatic breast cancer

Starting dose of CDK4/6 inhibitors linked to survival in metastatic breast cancer

Early-onset fever tied to severe cytokine release syndrome, multiple tocilizumab doses

Early-onset fever tied to severe cytokine release syndrome, multiple tocilizumab doses

Pharmacist-led intervention improves BP control of patients on oral chemotherapy

Pharmacist-led intervention improves BP control of patients on oral chemotherapy

Proton therapy reirradiation confers survival benefits in head and neck cancer, with caveat

Proton therapy reirradiation confers survival benefits in head and neck cancer, with caveat

Low BMD, fracture risk upped in childhood cancer survivors

Low BMD, fracture risk upped in childhood cancer survivors

Immune checkpoint inhibitors carry some risk of hepatotoxicity

Immune checkpoint inhibitors carry some risk of hepatotoxicity

Objective response to systemic therapy linked to overall survival in unresectable HCC

Objective response to systemic therapy linked to overall survival in unresectable HCC