News & Updates

COVID-19 shots for tots OK’d

01 Jul 2022 by

The 2-year wait is over.

COVID-19 shots for tots OK’d

01 Jul 2022

Persistent ALT elevation triples risk of future T2D among overweight, obese children

30 Jun 2022 by

Children with overweight or obesity risk developing future type 2 diabetes (T2D) by threefold in the presence of persistent elevations in alanine aminotransferases (ALT), according to a study presented at the 54th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN 2022).

Persistent ALT elevation triples risk of future T2D among overweight, obese children

30 Jun 2022

Methotrexate proven safe, effective as first-line immunomodulator in paediatric CD

30 Jun 2022 by

Use of methotrexate (MTX) appears safe and effective as first-line immunomodulator for maintenance therapy in children with Crohn’s disease (CD), suggests a study presented at the 54th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN 2022).

Methotrexate proven safe, effective as first-line immunomodulator in paediatric CD

30 Jun 2022

High leucine tied to worse executive function in kids

30 Jun 2022 by

Executive function (EF) in children appears to be linked to the metabolome, particularly with the amino acid leucine, higher levels of which seem to worsen EF and memory in this population, according to a recent Singapore study.

High leucine tied to worse executive function in kids

30 Jun 2022

Original New Drug Application Approvals by US FDA (16 - 30 June 2022)

30 Jun 2022

New drug applications approved by US FDA as of 16 - 30 June 2022 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16 - 30 June 2022)

30 Jun 2022

Cardiac size reduced in malnourished children

29 Jun 2022 by

Cardiothoracic ratios (CTR) are lower than the mean and R wave amplitudes are decreased in acutely malnourished children, reports a preliminary study presented at the 54th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN 2022).

Cardiac size reduced in malnourished children

29 Jun 2022

$Prucalopride offers relief in children with refractory idiopathic constipation$

Prucalopride offers relief in children with refractory idiopathic constipation

28 Jun 2022 by

Three out of five teens with refractory constipation achieve improvements in bowel movement with prucalopride, while having acceptable side effect profiles, as shown in a small study.

Prucalopride offers relief in children with refractory idiopathic constipation

28 Jun 2022

Tacrolimus-based treatment induces slower response in children with autoimmune liver disease

28 Jun 2022 by

Patients with paediatric-onset autoimmune liver disease show slower early immunological and biochemical response to a tacrolimus-based treatment as compared with regimens using prednisolone or azathioprine, reports a study presented at the 2022 Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN 2022).

Tacrolimus-based treatment induces slower response in children with autoimmune liver disease

28 Jun 2022

Brentuximab vedotin + chemo ups EFS in high-risk paediatric Hodgkin lymphoma

28 Jun 2022 by

The combination of brentuximab vedotin (Bv) and chemotherapy was superior to a standard paediatric dose-intensive chemotherapy regimen in boosting event-free survival (EFS) in paediatric patients with high-risk Hodgkin lymphoma (HL), according to the phase III AHOD1331* trial presented at ASCO 2022.

Brentuximab vedotin + chemo ups EFS in high-risk paediatric Hodgkin lymphoma

28 Jun 2022

Response analysis further establishes tezepelumab benefit in severe uncontrolled asthma

27 Jun 2022 by

Adolescents and adults with severe uncontrolled asthma while on inhaled corticosteroids (ICS) had greater responses to the human monoclonal antibody tezepelumab than placebo, according to prespecified exploratory results of the phase III NAVIGATOR trial.

Response analysis further establishes tezepelumab benefit in severe uncontrolled asthma

27 Jun 2022

News & Updates

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COVID-19 shots for tots OK’d

COVID-19 shots for tots OK’d

Persistent ALT elevation triples risk of future T2D among overweight, obese children

Persistent ALT elevation triples risk of future T2D among overweight, obese children

Methotrexate proven safe, effective as first-line immunomodulator in paediatric CD

Methotrexate proven safe, effective as first-line immunomodulator in paediatric CD

High leucine tied to worse executive function in kids

High leucine tied to worse executive function in kids

Original New Drug Application Approvals by US FDA (16 - 30 June 2022)

Original New Drug Application Approvals by US FDA (16 - 30 June 2022)

Cardiac size reduced in malnourished children

Cardiac size reduced in malnourished children

Prucalopride offers relief in children with refractory idiopathic constipation

Prucalopride offers relief in children with refractory idiopathic constipation

Tacrolimus-based treatment induces slower response in children with autoimmune liver disease

Tacrolimus-based treatment induces slower response in children with autoimmune liver disease

Brentuximab vedotin + chemo ups EFS in high-risk paediatric Hodgkin lymphoma

Brentuximab vedotin + chemo ups EFS in high-risk paediatric Hodgkin lymphoma

Response analysis further establishes tezepelumab benefit in severe uncontrolled asthma

Response analysis further establishes tezepelumab benefit in severe uncontrolled asthma