News & Updates

GDC-0214, an inhaled Janus kinase (JAK) inhibitor, induces dose-dependent reductions in fractional exhaled nitric oxide in patients with mild asthma, a recent study has found.

Palbociclib plus letrozole as first-line treatment improves progression-free survival (PFS) vs placebo plus letrozole in postmenopausal Asian patients with advanced oestrogen receptor (ER)–positive and HER2-negative breast cancer (BC), primary results of the phase III PALOMA-4 study have shown. 

Elevated counts of circulating endothelial progenitor cells (cEPCs) are correlated to worse anxiety, more severe depressive symptoms, poorer cognitive performance, greater social disability, and impaired overall mental health in patients with major depressive disorder (MDD), a recent study has found.

In the treatment of patients with type 2 diabetes mellitus and hypertension, switching from a dipeptidyl peptidase-4 (DPP-4) inhibitor to the sodium-glucose cotransporter-2 (SGLT2) inhibitor luseogliflozin appears to have favourable effects on blood pressure (BP), circadian rhythm, and night-time systolic BP (SBP) and pulse rate (PR), according to data from the open-label LUNA trial.

The addition of corticosteroids (ie, prednisolone) to NSAID eyedrops (ie, ketorolac) did not provide additional benefit relative to ketorolac alone or dropless surgery using a sub-Tenon capsule depot as an anti-inflammatory prophylactic regimen to prevent postoperative central macular thickening following uncomplicated cataract surgery, a Danish study suggests.

Long-term medical therapy in patients with primary aldosteronism (PA) is held back by dose-dependent side effects, according to a recent Singapore study.