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Tricyclic antidepressant for IBS worth a try
The tricyclic antidepressant amitriptyline, when used at low dose in the second-line treatment setting and titrated according to symptom response and side-effects, is safe and provides relief from symptoms of irritable bowel syndrome (IBS), as shown in the phase III ATLANTIS* trial.
Tricyclic antidepressant for IBS worth a try
15 Jan 2024
Can SLN mapping replace lymphadenectomy for surgical staging of early-stage EEC?
Researchers from the KK Women’s and Children’s Hospital, Singapore found that sentinel lymph node (SLN) mapping is an acceptable and safe alternative to routine lymphadenectomy in the surgical staging of early-stage endometrioid endometrial cancer (EEC).
Can SLN mapping replace lymphadenectomy for surgical staging of early-stage EEC?
15 Jan 2024
Antivirals underutilized after curative resection of HBV- or HCV-related HCC
Antiviral therapy is associated with substantial improvements in long-term overall survival (OS) but severely underutilized after curative hepatic resection in patients with hepatitis B virus (HBV)– or hepatitis C virus (HCV)–related hepatocellular carcinoma (HCC), a real-world study involving predominantly Asian patients has shown.
Antivirals underutilized after curative resection of HBV- or HCV-related HCC
15 Jan 2024
Repotrectinib shows high response rates, durable activity in ROS1 fusion–positive NSCLC
The next-generation ROS1 and TRK tyrosine kinase inhibitor (TKI) repotrectinib has demonstrated high response rates and durable activity in patients with ROS1 fusion–positive non-small-cell lung cancer (NSCLC), regardless of whether they have previously received ROS1 TKI therapy, according to phase II results of the ongoing registrational TRIDENT-1 trial.
