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Can vitamin D prevent severe COVID-19 outcomes in older people?
Vitamin D deficiency is common in modern society, particularly among older people who are homebound. Vitamin D supplements in older people may have a role in preventing serious complications of COVID-19, according to data presented at AIM 2022.

HBcrAg, HBsAb levels tied to persistent functional chronic hepatitis B cure
In chronic hepatitis B (CHB) patients treated with pegylated interferon alpha (peg-IFN-α)-based interventions, lower levels of the HB core-related antigen (HBcrAg) and higher levels of the HB surface antibody (HbsAb) are associated with durable functional cure, a recent study has found,

How effective were oral antivirals during HK’s Omicron BA.2 wave?
A real-world study during Hong Kong’s Omicron BA.2 wave showed that both molnupiravir and nirmatrelvir/ritonavir effectively lowered the risks of disease progression and all-cause mortality in hospitalized COVID-19 patients not requiring oxygen supplementation on admission. However, mortality risk reduction was larger with nirmatrelvir/ritonavir vs molnupiravir.

Pandemic-caused treatment delays for cancer may aggravate psychological distress
Cancer patients who experience treatment delays due to the COVID-19 pandemic restrictions may be vulnerable to psychological distress, reports a recent China study. Effective communication from doctors and other cancer care professionals may help mitigate this effect.

Autoantibodies against type 1 interferons increase COVID-19 death risk
The presence of autoantibodies neutralizing type 1 interferons (IFN), such as IFN-α2 or IFN-ω, strongly increase the relative risk of death (RRD) and infection fatality rate (IFR) in unvaccinated patients with COVID-19, according to a recent study.




