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Navitoclax–ruxolitinib combo doubles spleen response rates in myelofibrosis

Navitoclax–ruxolitinib combo doubles spleen response rates in myelofibrosis

17 Aug 2024 byJairia Dela Cruz

In untreated myelofibrosis, using navitoclax in combination with ruxolitinib appears to result in a twofold increase in the number of patients experiencing spleen volume shrinkage, regardless of prognosis, according to updated data from the phase III TRANSFORM-1 trial.

17 Aug 2024
Sildenafil shows promise as treatment for Alzheimer’s disease

Sildenafil shows promise as treatment for Alzheimer’s disease

15 Aug 2024 byStephen Padilla

Sildenafil, a phosphodiesterase type 5 inhibitor, can be a potential treatment for Alzheimer’s disease (AD), as shown in real-world data, AD patient-induced pluripotent stem cells (iPSC)-derived neuron models, and in vivo transgenic mouse model observations, according to a study presented at AAIC 2024.

15 Aug 2024