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Fracture risk not higher with SGLT2 vs DPP4 inhibitors
The use of sodium-glucose transporter 2 (SGLT2) inhibitors among patients with diabetes does not pose an increased risk of developing fractures as compared with dipeptidyl-peptidase 4 (DPP4) inhibitors, and this is true across estimated glomerular filtration rate (eGFR) and albuminuria categories, as shown in a study.
Gefitinib plus chemotherapy improves survival outcomes in mutated NSCLC brain metastases
Treatment with the combination of gefitinib and chemotherapy appears to yield significant increases in progression-free survival (PFS), intracranial PFS, and overall survival in patients with untreated EGFR-mutant non-small cell lung cancer (NSCLC) brain metastases as compared gefitinib monotherapy, according to the results of the phase III GAP BRAIN study.
Immune-mediated reactions predict survival in nivolumab-treated NSCLC patients
Several patients with nonsmall cell lung cancer (NSCLC) treated with nivolumab report developing immune-related adverse events (irAEs), primarily affecting the skin, lungs, and gastrointestinal system, according to a study.
Counselling, pamphlets boost flu vaccine intake in SG
Use of educational pamphlets alone and individualized counselling (IC) both lead to improved uptake of influenza vaccination, reports a Singapore study, noting that IC is not superior to pamphlets alone in increasing uptake.
GLP-1 agonists induce weight loss in diabetic patients with obesity
Initiation of a glucagon-like peptide-1 (GLP-1) agonist at standard glycaemic control doses may result in modest weight loss through 72 weeks in patients with overweight or obesity and type 2 diabetes, suggest the results of a real-world study.
Hydrochlorothiazide–lisinopril combo bests nifedipine for BP control in postpartum hypertension
In women with postpartum hypertension, treatment with combined hydrochlorothiazide (HCTZ)/lisinopril yields greater blood pressure (BP)-lowering benefit than nifedipine monotherapy, according to the results of a pilot study.