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Acute kidney injury more prevalent among patients on antibiotic combo vs monotherapy

16 Oct 2021

Treatment with the combination of vancomycin and piperacillin/tazobactam (VAN + PTZ) appears to be associated with a greater prevalence of acute kidney injury as compared with VAN or PTZ monotherapy or with the concurrent use of VAN and cefepime or carbapenem, a study reports.

Acute kidney injury more prevalent among patients on antibiotic combo vs monotherapy

16 Oct 2021

Abrocitinib trumps dupilumab for itch relief in eczema

16 Oct 2021 by

The oral selective JAK*1 inhibitor abrocitinib is superior to dupilumab for relieving itch and achieving skin clearance in people with moderate-to-severe atopic dermatitis (AD), according to results from a head-to-head comparison in the JADE DARE trial presented at EADV 2021.

Abrocitinib trumps dupilumab for itch relief in eczema

16 Oct 2021

Hydroxychloroquine use does not increase risk of heart failure in RA patients

15 Oct 2021 by

Use of hydroxychloroquine (HCQ) does not contribute to the development of heart failure (HF) in patients with rheumatoid arthritis (RA), a study has shown.

Hydroxychloroquine use does not increase risk of heart failure in RA patients

15 Oct 2021

Methotrexate–leflunomide combo safe in rheumatoid arthritis

15 Oct 2021

Methotrexate (MTX) plus leflunomide (LEF) demonstrates a relatively good safety profile overall compared with the combination of MTX and sulfasalazine (SSZ) and strategies involving advanced therapies in rheumatoid arthritis (RA), reports a study.

Methotrexate–leflunomide combo safe in rheumatoid arthritis

15 Oct 2021

Anxiety, depression up risk of persistent opioid use in women undergoing hysterectomy

15 Oct 2021

Opioid fills are common among women who have undergone hysterectomy, and those with preoperative anxiety and depression are more prone to persistent use and related complications, according to a study.

Anxiety, depression up risk of persistent opioid use in women undergoing hysterectomy

15 Oct 2021

Original New Drug Application Approvals by US FDA (01-15 October 2021)

15 Oct 2021

New drug applications approved by US FDA as of 01-15 October 2021 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (01-15 October 2021)

15 Oct 2021

Baricitinib: A potential treatment for alopecia areata?

14 Oct 2021 by

Baricitinib, an oral, selective Janus kinase (JAK)1/JAK2 inhibitor, may help improve hair growth in patients with severe alopecia areata, according to results from the phase III BRAVE-AA1 and BRAVE-AA2 trials.

Baricitinib: A potential treatment for alopecia areata?

14 Oct 2021

Abnormal nighttime BP doubles death risk in diabetes patients

14 Oct 2021 by

For adults with diabetes, increased blood pressure (BP) at night (reverse dipping) was associated with more than double the risk of death compared with those whose BP dipped as expected at night, according to the longitudinal CHAMP1ON study presented at Hypertension 2021.

Abnormal nighttime BP doubles death risk in diabetes patients

14 Oct 2021

Second bDMARD after failure of non-TNFi biologic in RA shows modest drug survival, response

14 Oct 2021

A recent study has shown modest drug survival and primary response of a second biologic disease-modifying antirheumatic drug (bDMARD) in patients with rheumatoid arthritis (RA) switching due to failure of a nontumour necrosis factor inhibitor (non-TNFi) bDMARD as the first agent.

Second bDMARD after failure of non-TNFi biologic in RA shows modest drug survival, response

14 Oct 2021

Smoking reduces effect of methotrexate-based treatment in RA patients

14 Oct 2021

Current smoking reduces the response of patients with early rheumatoid arthritis (RA) to methotrexate (MTX) in a dose-responsive manner, regardless of concomitant prednisone use, a recent study has found.

Smoking reduces effect of methotrexate-based treatment in RA patients

14 Oct 2021

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Acute kidney injury more prevalent among patients on antibiotic combo vs monotherapy

Acute kidney injury more prevalent among patients on antibiotic combo vs monotherapy

Abrocitinib trumps dupilumab for itch relief in eczema

Abrocitinib trumps dupilumab for itch relief in eczema

Hydroxychloroquine use does not increase risk of heart failure in RA patients

Hydroxychloroquine use does not increase risk of heart failure in RA patients

Methotrexate–leflunomide combo safe in rheumatoid arthritis

Methotrexate–leflunomide combo safe in rheumatoid arthritis

Anxiety, depression up risk of persistent opioid use in women undergoing hysterectomy

Anxiety, depression up risk of persistent opioid use in women undergoing hysterectomy

Original New Drug Application Approvals by US FDA (01-15 October 2021)

Original New Drug Application Approvals by US FDA (01-15 October 2021)

Baricitinib: A potential treatment for alopecia areata?

Baricitinib: A potential treatment for alopecia areata?

Abnormal nighttime BP doubles death risk in diabetes patients

Abnormal nighttime BP doubles death risk in diabetes patients

Second bDMARD after failure of non-TNFi biologic in RA shows modest drug survival, response

Second bDMARD after failure of non-TNFi biologic in RA shows modest drug survival, response

Smoking reduces effect of methotrexate-based treatment in RA patients

Smoking reduces effect of methotrexate-based treatment in RA patients