News &amp; Updates

Long-term treatment with alirocumab with or without lipid-lowering therapy treatment significantly reduced the levels of low-density lipoprotein cholesterol (LDL-C) in patients with acute coronary syndrome (ACS), as shown by the results of a real-world evidence study.

Alirocumab lowers LDL-C levels in patients with ACS

Sleep duration mediates link between screen time in late childhood and depression

Children who spend more screen time are at increased risk of having more depressive symptoms, potentially due to shorter sleep and worse white matter organization during early adolescence, according to a study.

Sleep duration mediates link between screen time in late childhood and depression

Raludotatug deruxtecan shows efficacy signal in platinum-sensitive ovarian cancer

07 Sep 2025 by

The cadherin 6 (CDH6)-directed antibody–drug conjugate raludotatug deruxtecan elicits response in heavily pretreated patients with platinum-sensitive ovarian cancer while having a manageable safety profile, according to a subgroup analysis of an ongoing first-in-human phase I trial.

Raludotatug deruxtecan shows efficacy signal in platinum-sensitive ovarian cancer

Is selective dorsal neurectomy/cryoablation effective for premature ejaculation?

The use of selective dorsal neurectomy (SDN)/cryoablation (CA) as a treatment option for patients with premature ejaculation remains controversial, according to a study. SDN/CA affects intravaginal ejaculatory latency time (IELT) and patient satisfaction.

Is selective dorsal neurectomy/cryoablation effective for premature ejaculation?

Short-term exposure to ozone air pollution ups risks of hospital admissions for MI, stroke

Individuals with short-term exposure to ozone (O3) air pollution are at risk of myocardial infarction (MI) and stroke requiring hospitalization, according to a systematic review and meta-analysis.

Short-term exposure to ozone air pollution ups risks of hospital admissions for MI, stroke

Thumbs up for rucaparib maintenance across prognostic subgroups of HRD-negative ovarian cancer

06 Sep 2025 by

Maintenance with the PARP inhibitor rucaparib after first-line platinum-doublet chemotherapy and cytoreductive surgery appears to reduce the risk of progression in the homologous recombination deficiency (HRD)-negative population of patients with advanced, high-grade ovarian cancer enrolled in the phase III ATHENA-MONO trial, no matter the prognostic factor.

Thumbs up for rucaparib maintenance across prognostic subgroups of HRD-negative ovarian cancer

Chlorthalidone trumps HCTZ for stone prevention; morning dosing preferable

06 Sep 2025 by

Calcium stone formers prefer the long-acting and more effective chlorthalidone for stone prevention, reports a study. The time of administration appears irrelevant, but morning administration may be more effective in addressing higher postdinner calcium excretion.

Chlorthalidone trumps HCTZ for stone prevention; morning dosing preferable

Teens with dysmenorrhea prone to chronic pain as adults

Dysmenorrhoea in adolescence appears to contribute to an increased risk of chronic pain in adulthood, according to a study.

Teens with dysmenorrhea prone to chronic pain as adults

Selinexor maintenance shows consistent benefit in TP53wt endometrial cancer

06 Sep 2025 by

Selinexor maintenance therapy continues to show consistent clinical benefit in patients with TP53 wild-type (TP53wt) advanced or recurrent endometrial cancer, regardless of mismatch repair (MMR) status, according to the ENGOT-EN5/GOG-3055/SIENDO trial presented at ESMO Gyn 2025.

Selinexor maintenance shows consistent benefit in TP53wt endometrial cancer