News & Updates

Among the cases of calcium channel blocker (CCB) overdose, dihydropyridines are the most common, with amlodipine accounting for nearly half. On the other hand, more severe toxicities occur with the use of verapamil and diltiazem.

The American College of Cardiology and the American Heart Association (ACC/AHA) have issued new guidelines for managing acute coronary syndromes (ACS), outlining strategies for lipid management, minimizing bleeding risk, and considerations related to procedural care.

Prenatal exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) has the potential to harm the offspring’s kidney health, highlighting the need for caution when prescribing NSAIDs during pregnancy, according to a large study from Taiwan.

Preoperative treatment with the oral nonsteroidal selective ER degrader elacestrant appears to yield biological and molecular responses in early-stage breast cancer, while having a manageable safety profile, as shown in a phase I trial.

Treatment with esketamine as an add-on to antidepressants shows modest efficacy in adults with treatment-resistant depression, reports a study. Its effect on suicidality, however, is not significant.

New drug applications approved by US FDA as of 1-15 March 2025 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.