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LIBERTY-UC: Maintenance subcutaneous infliximab eases moderate-to-severe UC
The subcutaneous infliximab formulation CT-P13 appears beneficial in the maintenance treatment of patients with moderately to severely active ulcerative colitis (UC), with data from the phase III study LIBERTY-UC showing that the drug outperforms placebo in multiple endpoints.
LIBERTY-UC: Maintenance subcutaneous infliximab eases moderate-to-severe UC
22 May 2023Natriuretic response to acetazolamide predicts decongestion in acute heart failure
A robust association exists between increased natriuresis and successful decongestion with acetazolamide in patients with acute decompensated heart failure (ADHF), suggests a study.
Natriuretic response to acetazolamide predicts decongestion in acute heart failure
22 May 2023Dupilumab cuts exacerbations, improves lung function in paediatric asthma patients with high eosinophils
In the post hoc analysis of data from the phase III LIBERTY ASTHMA VOYAGE study, the monoclonal antibody dupilumab reduced exacerbations and improved lung function in children aged between 6 and 11 years with moderate-to-severe asthma and baseline blood eosinophil count of ≥500 cells/μL.
Dupilumab cuts exacerbations, improves lung function in paediatric asthma patients with high eosinophils
22 May 2023Panitumumab plus trifluridine-tipiracil confers survival advantage in RAS wild-type MCRC
In the third-line treatment of patients with refractory RAS wild-type metastatic colorectal cancer (MCRC), use of panitumumab plus the standard-of-care trifluridine-tipiracil appears to prolong progression-free survival (PFS) when compared with trifluridine-tipiracil alone, according to data from a phase II study.
Panitumumab plus trifluridine-tipiracil confers survival advantage in RAS wild-type MCRC
21 May 2023Herbal combination works in treatment of active ulcerative colitis
The herbal combination of curcumin plus QingDai (CurQD) appears beneficial to patients with active ulcerative colitis (UC), with a recent study showing that the combination induced clinical and biomarker remission.
Herbal combination works in treatment of active ulcerative colitis
20 May 2023Broad-spectrum antibiotic exposure ups risk of IBD
Exposure to broad-spectrum antibiotics may put individuals at risk of developing inflammatory bowel disease (IBD), such that the greater the dose, the higher the risk, as shown in a study.
Broad-spectrum antibiotic exposure ups risk of IBD
20 May 2023Topiramate, phentermine for children with obesity hold up in the real world
Treatment with phentermine, topiramate, or their combination appears to help children with severe, complicated obesity shed weight, according to real-world data.