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Post-diagnosis use of risk stratification tools improves assessment of SMM patients
Despite only being validated for use at diagnosis, risk stratification scores, such as the Mayo-2018 and the International Myeloma Working Group (IMWG)-2020 criteria, appear to be viable for post-diagnosis use in patients with smouldering multiple myeloma (SMM), a recent study has found.
Post-diagnosis use of risk stratification tools improves assessment of SMM patients
29 Dec 2021
Interval between biopsy and RARP does not impact biochemical recurrence in prostate cancer
A prolonged gap between biopsy and robot-assisted radical prostatectomy (RARP) does not significantly influence the likelihood of biochemical recurrence (BCR) in prostate cancer patients, even in those who are considered high-risk, a recent Japan study has found.
Interval between biopsy and RARP does not impact biochemical recurrence in prostate cancer
28 Dec 2021
Venetoclax + chemo disappoints in double-hit lymphoma trial
In patients with double-hit lymphoma (DHL), the addition of the BCL2 inhibitor venetoclax to a chemoimmunotherapeutic regimen comprising DA-EPOCH-R* led to excess treatment-related mortality compared with DA-EPOCH-R alone, according to the initial results of the phase II/III Alliance A051701 trial.
Venetoclax + chemo disappoints in double-hit lymphoma trial
27 Dec 2021
Asian-derived polygenic risk scores boost risk stratification for breast cancer
Drawing from the largest available studies of Asian breast cancer patients, a recent Singapore study has developed polygenic risk scores (PRS) that can help improve the risk stratification of women of Asian ancestry.
Asian-derived polygenic risk scores boost risk stratification for breast cancer
27 Dec 2021
Sintilimab-IBI305-chemo improves PFS in EGFRm non-squamous NSCLC
The combination of the anti-PD-1 monoclonal antibody sintilimab with the bevacizumab biosimilar IBI305 and pemetrexed and cisplatin chemotherapy improved progression-free survival (PFS) in patients with EGFR*-mutated (EGFRm) non-squamous non-small-cell lung cancer (NSCLC), according to interim analysis results of the phase III ORIENT-31 trial from China.
Sintilimab-IBI305-chemo improves PFS in EGFRm non-squamous NSCLC
24 Dec 2021
Repeat surgery plus chemo may improve survival in recurrent ovarian cancer
The DESKTOP* III trial has shown that patients whose ovarian cancer recurs have better overall survival (OS) following secondary cytoreductive surgery plus platinum-based chemotherapy compared with a platinum-based chemotherapy regimen alone.
Repeat surgery plus chemo may improve survival in recurrent ovarian cancer
23 Dec 2021
Aumolertinib a win in EGFR T790M-positive advanced NSCLC
The novel third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) aumolertinib appears to be effective in the treatment of patients with EGFR T790M-positive advanced nonsmall cell lung carcinoma (NSCLC) following progression on first- and second-generation EGFR TKI therapy, according to data from the phase II APOLLO Registrational Trial.