News &amp; Updates

Studies examining the impact of strategies to improve treatment adherence to tyrosine kinase inhibitors (TKIs) for chronic myeloid leukaemia have relied on large data sets instead of prospective trials, according to the results of a systematic review. In addition, current studies lack patient-focused interventions.

Patient-focused strategies needed to improve adherence to TKI for chronic myeloid leukaemia

Clinical uncertainty on recurrent glioblastoma management proves need for trial

Clinical uncertainty and equipoise concerning the question of reoperation for patients with recurrent glioblastoma (GBM) is enough to support the need for a randomized controlled trial (RCT), suggests a recent study.

Clinical uncertainty on recurrent glioblastoma management proves need for trial

Younger adults at greater risk of regional, distant rectal cancer

More and more young patients are developing regional and distant rectal cancer, a US study has found. Although patient age significantly predicts survival, chemotherapy seems ineffective in younger patients with localized and regional disease.

Younger adults at greater risk of regional, distant rectal cancer

Knowledge regarding hormone therapy poor among BRCA mutation carriers

Breast cancer patients who are BRCA mutation carriers seem to be mostly uninformed about the benefits and risks of hormone therapy, which may lead to poor perceptions of it, a recent study has found.

Knowledge regarding hormone therapy poor among BRCA mutation carriers

Sapanisertib-based combo beneficial to postmenopausal women with pretreated breast cancer

In postmenopausal women with pretreated everolimus-sensitive or everolimus-resistant breast cancer, use of sapanisertib plus exemestane or fulvestrant is safe and associated with promising clinical activity, according to the results of a phase IB/II trial.

Sapanisertib-based combo beneficial to postmenopausal women with pretreated breast cancer

Salvage cystectomy post-trimodality therapy tied to late complications

Salvage cystectomy following trimodality therapy for intravesical recurrence demonstrates similar intraoperative and early complication rate to primary cystectomy and primary cystectomy with prior history of nontrimodality therapy abdominal or pelvic radiotherapy, reports a study.

Salvage cystectomy post-trimodality therapy tied to late complications

Intense ADT tied to positive pathologic responses in prostate cancer

Intense neoadjuvant hormone therapy in high-risk localized prostate cancer is associated with favourable pathologic responses (tumour <5 mm) in nearly one of five patients, a phase II study has shown. In addition, pathologic responses are comparable between treatment groups.

Intense ADT tied to positive pathologic responses in prostate cancer