News & Updates

Resmetirom reduces bad cholesterol, restores thyroid hormones in NASH

12 Dec 2023 by

Treatment with resmetirom significantly reduced low-density lipoprotein cholesterol (LDL-C) and other atherogenic lipids, as well as restored thyroid hormone (TH) levels in patients with nonalcoholic steatohepatitis (NASH), according to two subgroup analyses of the MAESTRO-NASH trial presented at The Liver Meeting 2023.

Resmetirom reduces bad cholesterol, restores thyroid hormones in NASH

12 Dec 2023

Amivantamab-based regimens may alter EGFR-mutant NSCLC treatment paradigm in Asia

11 Dec 2023 by

Updates from two MARIPOSA trials presented at ESMO Asia 2023 underpin the potential of amivantamab-based regimens for the treatment of locally advanced or metastatic EGFR-mutated non-small cell lung cancer (EGFRm NSCLC) in Asian subgroups.

Amivantamab-based regimens may alter EGFR-mutant NSCLC treatment paradigm in Asia

11 Dec 2023

Myeloma patients may benefit from mezigdomide-dexamethasone doublet

08 Dec 2023 by

In a study evaluating heavily pretreated patients with relapsed and refractory multiple myeloma (R/R MM), the combination of mezigdomide and dexamethasone showed promising preliminary efficacy, with myelosuppression and infection as primary toxicities.

Myeloma patients may benefit from mezigdomide-dexamethasone doublet

08 Dec 2023

Concizumab holds promise for patients with haemophilia A or B with inhibitors

07 Dec 2023 by

In patients with haemophilia A (PwHA) or B (PwHB) with inhibitors, annualized bleeding rate (ABR) was lower with daily subcutaneous (SC) concizumab prophylaxis than with on-demand treatment, findings from the phase IIIa explorer7 trial have shown.

Concizumab holds promise for patients with haemophilia A or B with inhibitors

07 Dec 2023

Severe nonadherence to hydroxychloroquine for lupus may have adverse consequences

07 Dec 2023

Among patients receiving hydroxychloroquine for systemic lupus erythematosus (SLE), severe nonadherence to medication poses increased risks of SLE flare in the following year, early damage, and 5-year mortality, according to data from the SLICC* Inception Cohort.

Severe nonadherence to hydroxychloroquine for lupus may have adverse consequences

07 Dec 2023

Surgery bests oral med for boosting bone density in dialysis patients

06 Dec 2023

For patients undergoing peritoneal dialysis, parathyroidectomy yields bigger increases in the bone mineral density (BMD) of lumbar spine and femoral neck as well as decreases in osteopenia/osteoporosis, according to a study.

Surgery bests oral med for boosting bone density in dialysis patients

06 Dec 2023

Low-dose methotrexate may pose serious adverse event risk for older adults with CKD

05 Dec 2023 by

For older adults with chronic kidney disease (CKD) who are initiating a disease-modifying antirheumatic drug (DMARD), low-dose methotrexate appears to be associated with a heightened 90-day risk of serious adverse events compared with hydroxychloroquine, as shown in a study.

Low-dose methotrexate may pose serious adverse event risk for older adults with CKD

05 Dec 2023

How does combination therapy fare as second-line treatment for NSCLC with EGFR mutation?

05 Dec 2023

Combination therapy does not appear to have beneficial effects in terms of progression-free survival (PFS), overall response rate (ORR), disease control rate (DCR), and incidence of adverse events compared with monotherapy in patients with advanced nonsmall cell lung cancer (NSCLC) who failed first-line treatment with an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, a study has shown.

How does combination therapy fare as second-line treatment for NSCLC with EGFR mutation?

05 Dec 2023

NOACs help improve outcomes in AF with vascular disease

05 Dec 2023 by

A history of vascular disease appears to contribute to worse long-term outcomes in patients with atrial fibrillation (AF), but treatment with oral anticoagulation (OAC) helps, suggests a recent study.

NOACs help improve outcomes in AF with vascular disease

05 Dec 2023

Novel therapies tied to drop in colectomy rate in paediatric UC

05 Dec 2023

The risk of colectomy in paediatric onset ulcerative colitis (UC) has significantly decreased at the population level along with an increase in the use of immunosuppressants and antitumour necrosis factor (anti-TNF), reports a study.

Novel therapies tied to drop in colectomy rate in paediatric UC

05 Dec 2023

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Resmetirom reduces bad cholesterol, restores thyroid hormones in NASH

Resmetirom reduces bad cholesterol, restores thyroid hormones in NASH

Amivantamab-based regimens may alter EGFR-mutant NSCLC treatment paradigm in Asia

Amivantamab-based regimens may alter EGFR-mutant NSCLC treatment paradigm in Asia

Myeloma patients may benefit from mezigdomide-dexamethasone doublet

Myeloma patients may benefit from mezigdomide-dexamethasone doublet

Concizumab holds promise for patients with haemophilia A or B with inhibitors

Concizumab holds promise for patients with haemophilia A or B with inhibitors

Severe nonadherence to hydroxychloroquine for lupus may have adverse consequences

Severe nonadherence to hydroxychloroquine for lupus may have adverse consequences

Surgery bests oral med for boosting bone density in dialysis patients

Surgery bests oral med for boosting bone density in dialysis patients

Low-dose methotrexate may pose serious adverse event risk for older adults with CKD

Low-dose methotrexate may pose serious adverse event risk for older adults with CKD

How does combination therapy fare as second-line treatment for NSCLC with EGFR mutation?

How does combination therapy fare as second-line treatment for NSCLC with EGFR mutation?

NOACs help improve outcomes in AF with vascular disease

NOACs help improve outcomes in AF with vascular disease

Novel therapies tied to drop in colectomy rate in paediatric UC

Novel therapies tied to drop in colectomy rate in paediatric UC