Add-on danicopan improves outcomes in patients with PNH, cs-EVH
21 Jul 2023
byAudrey Abella
In the ongoing pivotal phase III ALPHA trial, add-on danicopan, an investigational first-in-class oral inhibitor of Factor D, appears better than placebo in increasing haemoglobin levels and maintaining disease control in individuals with paroxysmal nocturnal haemoglobinuria (PNH) and clinically significant extravascular haemolysis (cs-EVH) who were already on C5 inhibitors (ravulizumab or eculizumab).