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RNAi agent RG6346 shows promise for treatment of chronic HBV infection

17 Nov 2023

A first-in-human randomized, phase I study has provided evidence to support the clinical development of RG6346 as a therapeutic regimen for chronic hepatitis B virus (HBV) infection (CHB), with the goal of sustained hepatitis B surface antigen (HBsAg) loss in CHB patients.

RNAi agent RG6346 shows promise for treatment of chronic HBV infection

17 Nov 2023

Lepodisiran lowers lipoprotein(a) concentrations in early trial

17 Nov 2023

Treatment with lepodisiran yields dose-dependent and durable reductions in serum lipoprotein(a) levels while being well tolerated, according to the results of a phase I trial.

Lepodisiran lowers lipoprotein(a) concentrations in early trial

17 Nov 2023

TAVR outperforms surgery through 4 years in low-risk patients with severe AS

17 Nov 2023 by

Among low surgical-risk patients with severe aortic stenosis (AS), those who underwent transcatheter aortic valve replacement (TAVR) have better valve performance and clinical and haemodynamic outcomes up to 4 years compared with those who underwent surgical aortic valve replacement (SAVR), according to the EVOLUT Low Risk trial presented at TCT 2023.

TAVR outperforms surgery through 4 years in low-risk patients with severe AS

17 Nov 2023

Vaginal vs laparoscopic hysterectomy shortens recovery time at expense of greater postoperative pain

16 Nov 2023

In the treatment of benign gynaecologic conditions, vaginal hysterectomy is associated with shorter total operative and recovery time compared with laparoscopic hysterectomy but has the disadvantage of greater postoperative pain, according to a study.

Vaginal vs laparoscopic hysterectomy shortens recovery time at expense of greater postoperative pain

16 Nov 2023

CT scan radiation poses blood cancer risk in young people

16 Nov 2023 by

Exposure to increasing radiation doses from computed tomography (CT) examinations may put young people at increased risk of blood cancers, as reported in a large study.

CT scan radiation poses blood cancer risk in young people

16 Nov 2023

Physical activity aids in recovery of cardiopulmonary function after lung cancer surgery

16 Nov 2023

Cardiopulmonary function (CPF) recovery failure at 6 months after lung cancer surgery appears to be driven by reductions in lung function and moderate-to-vigorous physical activity (MVPA) from baseline to 2 weeks, suggests a study. Baseline PA and dyspnoea are also associated with the inability to recover CPF.

Physical activity aids in recovery of cardiopulmonary function after lung cancer surgery

16 Nov 2023

Older adults in SG display high levels of knowledge, attitude of COVID-19

16 Nov 2023 by

Most older adults living in Singapore have good knowledge of the common symptoms of COVID-19 and awareness of government-endorsed preventive measures, according to a recent study.

Older adults in SG display high levels of knowledge, attitude of COVID-19

16 Nov 2023

Which CPAP mode is more effective in patients with severe OSA?

16 Nov 2023

Auto-adjusted (APAP) and fixed continuous positive airway pressure (CPAP) demonstrate similar efficacy in the treatment of severe obstructive sleep apnoea (OSA), a study has shown. Both CPAP modes are also well tolerated by patients with OSA.

Which CPAP mode is more effective in patients with severe OSA?

16 Nov 2023

Low-sodium diet delivers rapid BP-lowering effect

16 Nov 2023 by

In the CARDIA-SSBP study, low sodium intake led to a rapid reduction in blood pressure (BP) in middle-aged individuals.

Low-sodium diet delivers rapid BP-lowering effect

16 Nov 2023

Remibrutinib for Sjögren’s syndrome impresses in phase II trial

16 Nov 2023

The selective potent oral BTK inhibitor remibrutinib has shown favourable efficacy and safety in the treatment of patients with Sjögren’s syndrome, according to the results of a phase II trial.

Remibrutinib for Sjögren’s syndrome impresses in phase II trial

16 Nov 2023

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RNAi agent RG6346 shows promise for treatment of chronic HBV infection

RNAi agent RG6346 shows promise for treatment of chronic HBV infection

Lepodisiran lowers lipoprotein(a) concentrations in early trial

Lepodisiran lowers lipoprotein(a) concentrations in early trial

TAVR outperforms surgery through 4 years in low-risk patients with severe AS

TAVR outperforms surgery through 4 years in low-risk patients with severe AS

Vaginal vs laparoscopic hysterectomy shortens recovery time at expense of greater postoperative pain

Vaginal vs laparoscopic hysterectomy shortens recovery time at expense of greater postoperative pain

CT scan radiation poses blood cancer risk in young people

CT scan radiation poses blood cancer risk in young people

Physical activity aids in recovery of cardiopulmonary function after lung cancer surgery

Physical activity aids in recovery of cardiopulmonary function after lung cancer surgery

Older adults in SG display high levels of knowledge, attitude of COVID-19

Older adults in SG display high levels of knowledge, attitude of COVID-19

Which CPAP mode is more effective in patients with severe OSA?

Which CPAP mode is more effective in patients with severe OSA?

Low-sodium diet delivers rapid BP-lowering effect

Low-sodium diet delivers rapid BP-lowering effect

Remibrutinib for Sjögren’s syndrome impresses in phase II trial

Remibrutinib for Sjögren’s syndrome impresses in phase II trial