News & Updates

High-resolution anorectal manometry (HR‐ARM) can be a noninvasive primary screening tool for Hirschsprung’s disease (HD), particularly in children ≤2 years old, as shown in a comprehensive retrospective analysis.

Pooled analysis of the ASSERT and ASSERT-EXT studies show sustained improvements in multiple parameters with odevixibat in individuals with Alagille syndrome (ALGS), thus reinforcing its role in the treatment of this multisystem genetic disorder.

Treatment with higher-dose dupilumab results in sustained improvements in histologic and endoscopic measures of eosinophilic esophagitis (EoE) in children, regardless of prior use of swallowed topical corticosteroids (STCs), according to a subanalysis presented at ESPGHAN 2024.

Two-thirds of patients with IBD treated at an IBD centre in Singapore required dose intensification (DI) while on ustekinumab, with over one-third of them achieving disease remission at 1 year, as shown in a retrospective observational study

The rates of acute kidney injury (AKI) and kidney failure appear to rise following colectomy, especially total colectomy or colectomy with a prolonged stroma, in patients with inflammatory bowel disease (IBD), according to a nationwide Swedish cohort study.

Budesonide oral suspension is well tolerated and superior to placebo at inducing remission in paediatric patients with eosinophilic esophagitis (EoE), with the high-dose formulation offering the best results, according to the results of the phase II/III PEDEOS-1 trial.