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Lebrikizumab–topical corticosteroid combo improves outcomes in moderate-to-severe AD

16 Jan 2023 by

Treatment with lebrikizumab, when combined with low- to mid-potency topical corticosteroid (TCS), helps reduce disease severity in adolescent and adult patients with moderate-to-severe atopic dermatitis (AD), with a safety profile consistent with that reported in previous AD studies, according to the phase III ADhere trial.

Lebrikizumab–topical corticosteroid combo improves outcomes in moderate-to-severe AD

16 Jan 2023

Guided bronchoscopy falls short of improving diagnostic yield for peripheral pulmonary lesions

16 Jan 2023

Advances in bronchoscopic technology have been increasingly applied for diagnosing peripheral pulmonary lesions, but a recent study has found that such advances have not translated to improved diagnostic yield.

Guided bronchoscopy falls short of improving diagnostic yield for peripheral pulmonary lesions

16 Jan 2023

Diet with hyperinsulinaemic potential ups risk of breast cancer

15 Jan 2023

Women with a dietary pattern contributing to hyperinsulinaemia and insulin resistance appear to be at increased risk of breast cancer, particularly estrogen-receptor (ER)-negative and human epidermal growth factor receptor 2 (HER2)-enriched tumours, reveals a study.

Diet with hyperinsulinaemic potential ups risk of breast cancer

15 Jan 2023

Tix–cil combo prevents COVID-19 complications in immunocompromised patients

15 Jan 2023

The combination of tixagevimab and cilgavimab (Tix-Cil) protects immunocompromised patients with suboptimal immune responses to vaccines from COVID-19 complications, results of a study have shown.

Tix–cil combo prevents COVID-19 complications in immunocompromised patients

15 Jan 2023

$PFS in relapsed/refractory CLL/SLL: Zanubrutinib triumphs over ibrutinib$

PFS in relapsed/refractory CLL/SLL: Zanubrutinib triumphs over ibrutinib

15 Jan 2023 by

The second-generation BTK* inhibitor zanubrutinib was superior to the standard-of-care ibrutinib in improving progression-free survival (PFS) among patients with relapsed/refractory chronic lymphocytic leukaemia (R/R CLL) or small lymphocytic lymphoma (SLL), according to results of the phase III ALPINE trial presented at ASH 2022.

PFS in relapsed/refractory CLL/SLL: Zanubrutinib triumphs over ibrutinib

15 Jan 2023

PPI exposure during early pregnancy poses no excess risk of congenital malformations

15 Jan 2023

The use of proton pump inhibitors (PPIs) during early pregnancy does not appear to put infants at increased risk of congenital malformations, as reported in a study. However, there seems to be a small risk increase for major congenital malformations and congenital heart defects.

PPI exposure during early pregnancy poses no excess risk of congenital malformations

15 Jan 2023

Folate, vitamin B6, vitamin B12: Certain nutrients help prevent metabolic syndrome

14 Jan 2023

Individuals with adequate levels of folate, vitamin B6, and vitamin B12 appear to be at lower risk of developing metabolic syndrome, a study has found.

Folate, vitamin B6, vitamin B12: Certain nutrients help prevent metabolic syndrome

14 Jan 2023

Obesity reduces adalimumab potency against hidradenitis suppurativa

14 Jan 2023

Adalimumab for the treatment of hidradenitis suppurativa appears to be less effective in patients with obesity, a study has found.

Obesity reduces adalimumab potency against hidradenitis suppurativa

14 Jan 2023

Elevated homocysteine level tied to higher NAFLD risk

14 Jan 2023

Circulating homocysteine and folate concentrations appear to play a significant role in the development of nonalcoholic fatty liver disease (NAFLD), a study has shown.

Elevated homocysteine level tied to higher NAFLD risk

14 Jan 2023

DOACs on par with VKAs in octogenarians with VTE

14 Jan 2023

Direct oral anticoagulants (DOACs) are as effective and safe as vitamin K antagonists (VKAs) among octogenarians with venous thromboembolism (VTE), a study has shown.

DOACs on par with VKAs in octogenarians with VTE

14 Jan 2023

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Lebrikizumab–topical corticosteroid combo improves outcomes in moderate-to-severe AD

Lebrikizumab–topical corticosteroid combo improves outcomes in moderate-to-severe AD

Guided bronchoscopy falls short of improving diagnostic yield for peripheral pulmonary lesions

Guided bronchoscopy falls short of improving diagnostic yield for peripheral pulmonary lesions

Diet with hyperinsulinaemic potential ups risk of breast cancer

Diet with hyperinsulinaemic potential ups risk of breast cancer

Tix–cil combo prevents COVID-19 complications in immunocompromised patients

Tix–cil combo prevents COVID-19 complications in immunocompromised patients

PFS in relapsed/refractory CLL/SLL: Zanubrutinib triumphs over ibrutinib

PFS in relapsed/refractory CLL/SLL: Zanubrutinib triumphs over ibrutinib

PPI exposure during early pregnancy poses no excess risk of congenital malformations

PPI exposure during early pregnancy poses no excess risk of congenital malformations

Folate, vitamin B6, vitamin B12: Certain nutrients help prevent metabolic syndrome

Folate, vitamin B6, vitamin B12: Certain nutrients help prevent metabolic syndrome

Obesity reduces adalimumab potency against hidradenitis suppurativa

Obesity reduces adalimumab potency against hidradenitis suppurativa

Elevated homocysteine level tied to higher NAFLD risk

Elevated homocysteine level tied to higher NAFLD risk

DOACs on par with VKAs in octogenarians with VTE

DOACs on par with VKAs in octogenarians with VTE