News &amp; Updates

Close blood pressure (BP) monitoring and more intensive and combined antihypertensive therapy are needed when there is a high prevalence of uncontrolled arterial hypertension (AH) despite the successful coarctation of the aorta (CoA) correction and use of relatively low doses of antihypertensive drugs, suggests a recent study.

Intensive antihypertensive therapy vital in kids with arterial hypertension after CoA repair

30 Nov 2022

Ascending aortic diameter predicts aortic dissection better than size index in Turner syndrome

Among women with Turner syndrome (TS), aortic dissection appears to be more correlated with the ascending aortic diameter (AAD) than with aortic size index (ASI), a new study has found. TS-specific z-score is also a reliable predictor of dissection.

Ascending aortic diameter predicts aortic dissection better than size index in Turner syndrome

Pituitary TF–based classification improves diagnostic accuracy and prognostication of nonfunctioning PitNETs

30 Nov 2022 by

Utility of pituitary transcription factors (TFs) improves the diagnostic accuracy and prognostication of nonfunctioning pituitary neuroendocrine tumours (NF-PitNETs), according to local data and a new diagnostic classification presented at the 5^th Annual Meeting of Endocrinology, Diabetes & Metabolism Hong Kong (EDM HK).

Pituitary TF–based classification improves diagnostic accuracy and prognostication of nonfunctioning PitNETs

30 Nov 2022

FRESCO-2: Fruquintinib improves OS in heavily pretreated mCRC

30 Nov 2022 by

Fruquintinib, a highly selective and potent oral tyrosine kinase inhibitor of VEGFR*-1, -2, and -3, significantly improves overall survival (OS) in heavily pretreated patients with metastatic colorectal cancer (mCRC), according to the FRESCO-2** trial presented at ESMO 2022.

FRESCO-2: Fruquintinib improves OS in heavily pretreated mCRC

MEFIB bests MAST, FAST for fibrosis detection in NAFLD

Magnetic resonance elastography (MRE) plus FIB-4 (MEFIB) outperforms both magnetic resonance imaging [MRI]-aspartate aminotransferase (MAST) and FibroScan-AST (FAST) in detecting stage ≥2 fibrosis and at-risk nonalcoholic steatohepatitis (NASH), reveals a study.

MEFIB bests MAST, FAST for fibrosis detection in NAFLD

Do aortic annular size, valve type affect outcomes after TAVI?

Aortic annular size does not appear to have a major impact on valve haemodynamics, prosthesis-patient match (PPM), and mortality following transcatheter aortic valve implantation (TAVI), according to the results of a Singapore study.

Do aortic annular size, valve type affect outcomes after TAVI?

Intermittent fasting may not be healthy after all

Currently in vogue, intermittent fasting (IF) – which switches between periods of eating and fasting – may not be as beneficial as many have thought.

Intermittent fasting may not be healthy after all

Lung fibrosis extent on quantified CT predicts survival in IPF

The extent of fibrotic abnormality on baseline computed tomography (CT), quantified using data-driven texture analysis (DTA), is predictive of outcomes in patients with idiopathic pulmonary fibrosis (IPF), regardless of pulmonary function, suggests a study.

Lung fibrosis extent on quantified CT predicts survival in IPF

29 Nov 2022

Vilobelimab augments treatment armamentarium for critically ill COVID-19 patients

In the phase III part of the PANAMO trial, the anti-C5a monoclonal antibody vilobelimab, when added to standard of care (SoC), improved survival in COVID-19 patients who required invasive mechanical ventilation (IMV).

Vilobelimab augments treatment armamentarium for critically ill COVID-19 patients

29 Nov 2022

High-flow nasal cannula oxygen therapy better than CPAP in preterm infants

Compared with continuous positive airway pressure (CPAP), respiratory support using high-flow nasal cannula oxygen therapy (HNFC) appears to yield better clinical outcomes in preterm infants, according to a recent meta-analysis.

High-flow nasal cannula oxygen therapy better than CPAP in preterm infants