News &amp; Updates

There is no best time to initiate low-dose vaginal oestrogen therapy, since it improves the signs and symptoms of vaginal atrophy in both younger and older women, according to a posthoc analysis.

Vaginal atrophy treatment: Initiation at any age is fine, study says

Probiotics, paraprobiotics offer no clear sleep benefits

Currently, there is not enough evidence to support taking probiotics or paraprobiotics to help with subjective or objective sleep quality, reports a new meta-analysis. More studies with better experimental designs are needed to probe the subject further.

Probiotics, paraprobiotics offer no clear sleep benefits

Disordered REM sleep, constipation signal cognitive decline among Parkinson’s disease patients

Constipation and probable REM sleep behaviour disorder (RBD) are strong indicators of future cognitive decline in Parkinson’s disease (PD) patients, especially in men, a recent study has found.

Disordered REM sleep, constipation signal cognitive decline among Parkinson’s disease patients

Switching to B/F/TAF maintains HIV viral suppression in elderly

Switching to a single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) maintains virologic suppression over 72 weeks in older people living with HIV (PLWH), according to a study presented at the HIV Glasgow 2020 Congress.

Switching to B/F/TAF maintains HIV viral suppression in elderly

N-acetylcysteine prevents neurotoxicity in colorectal, gastric cancer patients

N-acetylcysteine provides a protective effect on chemotherapy-induced neuropathy by reducing its incidence and delaying its occurrence in patients with gastric or colorectal cancers, a study has shown.

N-acetylcysteine prevents neurotoxicity in colorectal, gastric cancer patients

Modified glutathione cream effective in mild-to-moderate rosacea

The modified glutathione (GSH-C4) with beta glycyrrhetic and azelaic acids cream is effective in the treatment of mild-to-moderate rosacea, with local tolerability consistent with other antirosacea medications, according to a study presented at the 29th Congress of the European Academy of Dermatology and Venereology (EADV 2020).

Modified glutathione cream effective in mild-to-moderate rosacea

Warfarin tied to more drug interactions than DOACs in cancer patients

Direct-acting oral anticoagulants (DOACs) have fewer drug–drug interactions (DDIs) than warfarin, but the severity of interaction varies between DOACs, a recent study has found. In addition, some anticoagulant-drug interactions correlate with bleeding or venous thromboembolism (VTE).

Warfarin tied to more drug interactions than DOACs in cancer patients

Upacicalcet may manage secondary hyperparathyroidism in dialysis patients

The administration of upacicalcet – a novel, small-molecule calcimimetic agent in late-stage development in Japan – led to a significant reduction in serum intact parathyroid hormone (iPTH) level without increasing upper gastrointestinal (GI) symptoms in patients who have secondary hyperparathyroidism following haemodialysis, according to a phase III trial presented at ASN Kidney Week 2020.

Upacicalcet may manage secondary hyperparathyroidism in dialysis patients

Empagliflozin not just another SGLT2i: Cardio-renal benefits extend to HF with or without diabetes

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Empagliflozin not just another SGLT2i: Cardio-renal benefits extend to HF with or without diabetes

$Meth-associated HF with reduced ejection fraction reversible$

Meth-associated HF with reduced ejection fraction reversible

Patients with methamphetamine-associated heart failure (HF) with reduced left ventricular (LV) ejection fraction (HFrEF) have a more severe disease compared with other HF patients, a study has found. But more importantly, quitting meth leads to an improvement in LV function with fewer hospital admissions, suggesting that meth-associated HFrEF may be reversed.

Meth-associated HF with reduced ejection fraction reversible