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HEART-FID confirms IV iron safety for HF but falls short in efficacy
The HEART-FID trial narrowly missed its primary endpoint, showing modest improvement in all-cause mortality, heart failure hospitalizations (hHF), and exercise function with ferric carboxymaltose (FCM) in HFrEF* patients with iron deficiency (ID).
HEART-FID confirms IV iron safety for HF but falls short in efficacy
11 Sep 2023
SMAD7 overexpression boosts EGFR-CAR-T function against NSCLC
Epidermal growth factor receptor (EGFR)-mothers against decapentaplegic homologue 7 (SMAD7)-Chimeric antigen receptor (CAR) T-cell therapy against nonsmall-cell lung cancer (NSCLC) is on a par with EGFR-dominant‒negative transforming growth factor (TGFbeta) receptor 2 (DNR)-CAR-T in terms of efficacy and resistance to negative TGFβ regulation, a study has shown.
SMAD7 overexpression boosts EGFR-CAR-T function against NSCLC
10 Sep 2023
Airflow limitation predicts muscle wasting in COPD patients
Severe airflow limitation tends to contribute to future muscle wasting in patients with chronic obstructive pulmonary disease (COPD) and ever-smokers at risk of COPD, reports a recent study.