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Nintedanib falls short in bladder cancer trial
In the phase II NEOBLADE* trial, the addition of the multikinase** inhibitor nintedanib to neoadjuvant chemotherapy (CT) consisting of gemcitabine and cisplatin failed to improve pathological complete response (pCR) and progression-free survival (PFS) in individuals with locally advanced muscle-invasive bladder cancer (MIBC).
Nintedanib falls short in bladder cancer trial
21 Jun 2022Ceritinib shows therapeutic potential in ALK-positive nonsmall cell lung cancer
The anaplastic lymphoma kinase (ALK) inhibitor ceritinib delivers favourable antitumour activity in ALK-mutated nonsmall cell lung cancer (NSCLC) patients with active brain metastases and/or leptomeningeal disease, according to the phase II ASCEND-7 trial.
Ceritinib shows therapeutic potential in ALK-positive nonsmall cell lung cancer
21 Jun 2022Bimekizumab triumphs in bDMARD-naïve psoriatic arthritis patients
Patients with psoriatic arthritis (PsA) with no prior exposure to biological disease-modifying antirheumatic drugs (bDMARDs) experience improvements in their condition when treated with bimekizumab, according to results of the phase III BE OPTIMAL trial.
Bimekizumab triumphs in bDMARD-naïve psoriatic arthritis patients
20 Jun 2022Vunakizumab safe, effective in moderate-to-severe plaque psoriasis
Treatment with vunakizumab, a novel interleukin 17A monoclonal antibody, shows promise for moderate-to-severe plaque psoriasis and good tolerability, according to the results of a recent study.
Vunakizumab safe, effective in moderate-to-severe plaque psoriasis
20 Jun 2022Antibiotic use for chronic endometritis poses risk of miscarriage after ART
The use of antibiotic therapy to resolve chronic endometritis can put women undergoing assisted reproductive treatment (ART) at heightened risk of pregnancy loss, according to a study.
Antibiotic use for chronic endometritis poses risk of miscarriage after ART
20 Jun 2022Ketogenic trials with Parkinson’s disease-specific outcomes lacking
The ketogenic diet, as well as ketogenic agents, has been shown to be a promising therapeutic regimen for Parkinson’s disease (PD) in animals, but research on humans is highly heterogenous and lacking PD-specific outcomes, according to a study.